Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HAT1 | O14929 | 1/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4320457 | 0.87 | MAPT (0.49) | TDP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4310933 | 0.86 | GABRP (0.42) | KDM4EHAT1EP300GABRA1GABRG2 | |
| SCHEMBL4302329 | 0.84 | ACHE (0.42) | TDP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4304075 | 0.84 | ALDH1A1 (0.42) | TDP1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1557626 | 0.77 | ALDH1A1 (0.47) | MEN1KMT2AALDH1A1MAPTGABRA1 | |
| SCHEMBL4310271 | 0.76 | ALDH1A1 (0.41) | TDP1ALDH1A1MAPTGABRA1GABRG2 | |
| SCHEMBL4311420 | 0.75 | MAPT (0.54) | MEN1GAAKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL22864631 | 0.74 | NR4A2 (0.54) | MEN1KMT2AALDH1A1KDM4EGABRA1 | |
| SCHEMBL29800593 | 0.74 | NR4A2 (0.54) | MEN1KMT2AALDH1A1KDM4EGABRA1 | |
| SCHEMBL4320477 | 0.72 | MAPT (0.47) | MEN1KMT2AALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | claimed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |