Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3124609 | 0.88 | ALDH1A1 (0.55) | ALDH1A1MAPTL3MBTL1GABRA1GABRB2 | |
| SCHEMBL3121013 | 0.88 | ALDH1A1 (0.40) | ALDH1A1MAPTL3MBTL1DRD2HTR2A | |
| SCHEMBL4304078 | 0.88 | MAPK14 (0.43) | ALDH1A1MAPTL3MBTL1DRD2HTR2A | |
| SCHEMBL3120950 | 0.87 | ALDH1A1 (0.40) | ALDH1A1MAPTL3MBTL1DRD2HTR2A | |
| SCHEMBL4312756 | 0.83 | HDAC1 (0.47) | ALDH1A1MAPTL3MBTL1ROCK2ROCK1 | |
| SCHEMBL4313368 | 0.83 | ALDH1A1 (0.43) | ALDH1A1MAPTL3MBTL1DRD2HTR2A | |
| SCHEMBL4312470 | 0.82 | ALDH1A1 (0.42) | ALDH1A1MAPTL3MBTL1DRD2HTR2A | |
| SCHEMBL4302329 | 0.80 | ACHE (0.42) | ALDH1A1MAPTGABRA1GABRB2GABRA3 | |
| SCHEMBL4304075 | 0.80 | ALDH1A1 (0.42) | ALDH1A1MAPTL3MBTL1GABRA1GABRB2 | |
| SCHEMBL4306639 | 0.80 | MAPK14 (0.37) | ALDH1A1MAPTL3MBTL1DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | claimed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |