SCHEMBL4305458

SCHEMBL4305458

C=Cc1ccc(C(=O)Nc2ccc(N)c3c2C(=O)c2ccccc2C3=O)cc1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.76
KMT2A Q03164 4/20 0.76
MMP14 P50281 1/20 0.76
HDAC2 Q92769 5/20 0.56
CYP1A2 P05177 1/20 0.49
TSHR P16473 1/20 0.49
CSNK1A1 P48729 2/20 0.47
CSNK1D P48730 2/20 0.47
CSNK1G1 Q9HCP0 2/20 0.47
ADORA2A P29274 2/20 0.47
FGR P09769 1/20 0.47
PIM1 P11309 1/20 0.47
MAOA P21397 1/20 0.47
DYRK1A Q13627 1/20 0.47
HIPK2 Q9H2X6 1/20 0.47
POLB P06746 3/20 0.46
BLM P54132 2/20 0.46
CCR6 P51684 1/20 0.46
RXFP1 Q9HBX9 1/20 0.46
PABPC1 P11940 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4299603 0.94 MEN1 (0.64) MEN1KMT2AMMP14HDAC2CYP1A2
SCHEMBL4291253 0.88 MEN1 (0.57) MEN1KMT2AMMP14HDAC2CYP1A2
SCHEMBL6141826 0.87 MEN1 (1.00) MEN1KMT2AMMP14HDAC2CYP1A2
SCHEMBL4293382 0.85 MEN1 (0.54) MEN1KMT2AMMP14HDAC2ADORA2A
SCHEMBL9846468 0.85 MEN1 (0.85) MEN1KMT2AMMP14HDAC2CYP1A2
SCHEMBL4654042 0.85 MAOA (0.56) MEN1KMT2AMMP14HDAC2CYP1A2
SCHEMBL9846531 0.85 MEN1 (0.80) MEN1KMT2AMMP14CYP1A2TSHR
SCHEMBL4285958 0.83 CASP3 (0.52) MEN1KMT2AMMP14HDAC2CYP1A2
SCHEMBL4286784 0.82 MEN1 (0.52) MEN1KMT2AMMP14HDAC2CYP1A2
SCHEMBL11139967 0.81 MEN1 (0.74) MEN1KMT2AMMP14HDAC2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023068316-A1 MATERIAL FOR SOFT CONTACT LENS HAVING CONTRAST IMPROVEMENT FUNCTION 興和株式会社 2023-04-27 WO disclosed
US-20210163650-A1 POLYMER MATERIAL MENICON CO., LTD. (JP) 2021-06-03 US disclosed
EP-3822296-A1 POLYMER MATERIAL Menicon Co., Ltd. (JP) 2021-05-19 EP disclosed
CN-104284942-A Stable polymerizable UV-absorbing colorant for intraocular lens KOWA CO 2015-01-14 CN disclosed
US-20130202551-A1 IONIC COMPOUND, COMPOSITION, CURED MATERIAL, HYDROGEL AND OPHTHALMIC LENS MENICON CO., LTD. (JP) 2013-08-08 US disclosed
EP-2581394-A1 IONIC COMPOUND, COMPOSITION, CURED PRODUCT, HYDROGEL, AND OCULAR LENS Menicon Co., Ltd. (JP) 2013-04-17 EP disclosed
EP-1696257-B1 CONTACT LENS MATERIAL MENICON CO LTD (JP) 2012-11-21 EP disclosed
US-20090247662-A1 Contact Lens Material MATSUMOTO MASAHIRO 2009-10-01 US disclosed
EP-1033590-B1 Ocular lens material MENICON CO LTD (JP) 2008-05-07 EP disclosed
US-20070149699-A1 Contact lens material MENICON CO., LTD. (JP) 2007-06-28 US disclosed
EP-0722110-B1 Water absorptive soft contact lens MENICON CO LTD (JP) 2003-09-17 EP disclosed
US-6329445-B1 Ocular lens material MENICON CO., LTD (JP) 2001-12-11 US disclosed
EP-0729041-B1 Water-Absorptive soft contact lens MENICON CO LTD (JP) 2001-11-28 EP disclosed
EP-1033590-A2 Ocular lens material Menicon Co., Ltd. (JP) 2000-09-06 EP disclosed
EP-0947856-A2 Ocular lens material Menicon Co., Ltd. (JP) 1999-10-06 EP disclosed
US-5786434-A A CURABLE COPOLYMER COMPRISING A DIALKYLACRYLAMIDE OR METHACRYLAMIDE, A VINYLLACTAM, A BIS(SILICON-CONTAINING ALKYL)FUMARATE MONOMERS; RADIATION TRANSPARENT, HIGH OXYGEN PERMEABILITY MENICON CO., LTD. (JP) 1998-07-28 US disclosed
US-5741830-A COPOLYMER OF A FLUORINE CONTAINING STYRENE DERIVATIVE AND N,N-DIMETHYL(METH)ACRYLAMIDE MENICON CO., LTD. (JP) 1998-04-21 US disclosed
US-5661194-A POLYMER FROM MONOMERS OF (METH)ACRYLAMIDE TYPE MONOMER, FLUOROALKYL (SILICON-CONTAINING ALKYL) FUMARATE MONOMER, AND CROSSLINKING MONOMER MENICON CO., LTD. (JP) 1997-08-26 US disclosed
EP-0729041-A2 Water-Absorptive soft contact lens Menicon Co., Ltd. (JP) 1996-08-28 EP disclosed
EP-0722110-A2 Water absorptive soft contact lens Menicon Co., Ltd. (JP) 1996-07-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130202551-A1 IONIC COMPOUND, COMPOSITION, CURED MATERIAL, HYDROGEL AND OPHTHALMIC LENS CRYZ, CRYAA, VIL1 MEN1 1583/4885KMT2A 3332/4885MMP14 1405/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.