SCHEMBL4293382

SCHEMBL4293382

C=Cc1ccc(C(=O)Nc2cccc3c2C(=O)c2cccc(N)c2C3=O)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.54
KMT2A Q03164 3/20 0.54
MMP14 P50281 1/20 0.54
HDAC2 Q92769 6/20 0.50
CASP3 P42574 3/20 0.47
HDAC1 Q13547 8/20 0.44
HDAC3 O15379 4/20 0.44
MAPK1 P28482 1/20 0.44
ADORA2A P29274 1/20 0.44
NCOR2 Q9Y618 1/20 0.44
MAOA P21397 1/20 0.44
PTGS1 P23219 1/20 0.42
HDAC6 Q9UBN7 2/20 0.42
HDAC4 P56524 2/20 0.41
HDAC7 Q8WUI4 2/20 0.41
HDAC10 Q969S8 1/20 0.41
HDAC11 Q96DB2 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
HDAC9 Q9UKV0 1/20 0.41
HDAC5 Q9UQL6 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4297792 0.96 MEN1 (0.50) MEN1KMT2AMMP14HDAC2CASP3
SCHEMBL4285958 0.94 CASP3 (0.52) MEN1KMT2AMMP14HDAC2CASP3
SCHEMBL4654042 0.90 MAOA (0.56) MEN1KMT2AMMP14HDAC2CASP3
SCHEMBL15153792 0.86 MEN1 (0.48) MEN1KMT2AMMP14HDAC2CASP3
SCHEMBL30611003 0.85 MEN1 (0.72) MEN1KMT2AMMP14HDAC2CASP3
SCHEMBL1982461 0.85 MEN1 (0.72) MEN1KMT2AMMP14HDAC2CASP3
SCHEMBL4305458 0.85 MEN1 (0.76) MEN1KMT2AMMP14HDAC2CASP3
SCHEMBL10726032 0.85 MEN1 (0.56) MEN1KMT2AMMP14HDAC2CASP3
SCHEMBL4299603 0.83 MEN1 (0.64) MEN1KMT2AMMP14HDAC2CASP3
SCHEMBL8777783 0.82 MEN1 (0.67) MEN1KMT2AMMP14HDAC2CASP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023068316-A1 MATERIAL FOR SOFT CONTACT LENS HAVING CONTRAST IMPROVEMENT FUNCTION 興和株式会社 2023-04-27 WO disclosed
US-20210163650-A1 POLYMER MATERIAL MENICON CO., LTD. (JP) 2021-06-03 US disclosed
EP-3822296-A1 POLYMER MATERIAL Menicon Co., Ltd. (JP) 2021-05-19 EP disclosed
CN-104284942-B Stable artificial lens polymerism ultraviolet radiation absorption pigment 兴和株式会社 2016-09-07 CN disclosed
CN-104284942-A Stable polymerizable UV-absorbing colorant for intraocular lens KOWA CO 2015-01-14 CN disclosed
US-20130202551-A1 IONIC COMPOUND, COMPOSITION, CURED MATERIAL, HYDROGEL AND OPHTHALMIC LENS MENICON CO., LTD. (JP) 2013-08-08 US disclosed
EP-2581394-A1 IONIC COMPOUND, COMPOSITION, CURED PRODUCT, HYDROGEL, AND OCULAR LENS Menicon Co., Ltd. (JP) 2013-04-17 EP disclosed
EP-1696257-B1 CONTACT LENS MATERIAL MENICON CO LTD (JP) 2012-11-21 EP disclosed
US-20090247662-A1 Contact Lens Material MATSUMOTO MASAHIRO 2009-10-01 US disclosed
EP-1033590-B1 Ocular lens material MENICON CO LTD (JP) 2008-05-07 EP disclosed
US-20070149699-A1 Contact lens material MENICON CO., LTD. (JP) 2007-06-28 US disclosed
EP-1696257-A1 CONTACT LENS MATERIAL MENICON CO., LTD. (JP) 2006-08-30 EP disclosed
US-6329445-B1 Ocular lens material MENICON CO., LTD (JP) 2001-12-11 US disclosed
EP-1033590-A2 Ocular lens material Menicon Co., Ltd. (JP) 2000-09-06 EP disclosed
EP-0947856-A2 Ocular lens material Menicon Co., Ltd. (JP) 1999-10-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130202551-A1 IONIC COMPOUND, COMPOSITION, CURED MATERIAL, HYDROGEL AND OPHTHALMIC LENS CRYZ, CRYAA, VIL1 MEN1 1583/4885KMT2A 3332/4885MMP14 1405/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.