Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | STS | P08842 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4010564 | 0.88 | EPHX2 (0.35) | CXCR2KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL4010678 | 0.86 | HSD11B1 (0.45) | LMNAEPHX2HSD11B1SMN1; SMN2 | |
| SCHEMBL4005033 | 0.86 | EPHX2 (0.35) | KMT2AMEN1LMNAALDH1A1ITGB1 | |
| SCHEMBL4009267 | 0.85 | HSD11B1 (0.39) | KMT2AMEN1LMNAALDH1A1EPHX2 | |
| SCHEMBL4006571 | 0.85 | HSD11B1 (0.43) | LMNAHSD11B1SMN1; SMN2 | |
| SCHEMBL4006598 | 0.84 | NPSR1 (0.41) | KMT2AMEN1LMNAALDH1A1HPGD | |
| SCHEMBL4307013 | 0.84 | MMP2 (0.39) | KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL4002524 | 0.81 | EPHX2 (0.48) | KMT2AMEN1LMNAALDH1A1EPHX2 | |
| SCHEMBL4292846 | 0.81 | EPHX2 (0.45) | EPHX2 | |
| SCHEMBL4306301 | 0.81 | EPHX2 (0.43) | KMT2AMEN1ALDH1A1HPGDEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778229-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-06-17 | — | — | EP | claimed |
| EP-1778229-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-05-02 | — | — | EP | claimed |
| WO-2006020598-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-23 | — | — | WO | claimed |