Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.78 |
| ▸ | HPGD | P15428 | 3/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.78 |
| ▸ | USP2 | O75604 | 1/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.78 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | SORT1 | Q99523 | 6/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.41 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3417720 | 0.94 | KDM4E (0.70) | KDM4EALDH1A1HPGDHSD17B10USP2 | |
| Triflusal SCHEMBL29435449 | 0.88 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10USP2 | |
| Triflusal SCHEMBL136423 | 0.88 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10USP2 | |
| Triflusal SCHEMBL29435450 | 0.88 | KDM4E (1.00) | KDM4EALDH1A1HPGDHSD17B10USP2 | |
| Triflusal SCHEMBL4960641 | 0.86 | KDM4E (0.97) | KDM4EALDH1A1HPGDHSD17B10USP2 | |
| SCHEMBL19294141 | 0.81 | KDM4E (0.67) | KDM4EALDH1A1HPGDHSD17B10USP2 | |
| SCHEMBL422034 | 0.81 | ALDH1A1 (0.71) | KDM4EALDH1A1HPGDHSD17B10USP2 | |
| SCHEMBL19294163 | 0.81 | KDM4E (0.71) | KDM4EALDH1A1HPGDHSD17B10USP2 | |
| Triflusal SCHEMBL2322418 | 0.80 | KDM4E (0.84) | KDM4EALDH1A1HPGDHSD17B10USP2 | |
| SCHEMBL4305509 | 0.78 | CYP2C19 (0.48) | KDM4EALDH1A1HPGDHSD17B10USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110060156-A1 | Pyruvate Derivatives with Neuroprotective Effect, Process for Preparing the Same and Pharmaceutical Composition Comprising the Same | S.H. PHARMA., LTD. (KR) | 2011-03-10 | — | — | US | claimed |
| WO-2009108017-A2 | NEW PYRUVATE DERIVATIVES WITH NEUROPROTECTIVE EFFECT, PROCESS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | S.H. PHARMA., LTD (KR) | 2009-09-03 | — | — | WO | claimed |
| US-20110060156-A1 | Pyruvate Derivatives with Neuroprotective Effect, Process for Preparing the Same and Pharmaceutical Composition Comprising the Same | S.H. PHARMA., LTD. (KR) | 2011-03-10 | — | — | US | disclosed |
| WO-2009108017-A2 | NEW PYRUVATE DERIVATIVES WITH NEUROPROTECTIVE EFFECT, PROCESS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | S.H. PHARMA., LTD (KR) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110060156-A1 | Pyruvate Derivatives with Neuroprotective Effect, Process for Preparing the Same and Pharmaceutical Composition Comprising the Same | PC, PDK1, PDK2 | KDM4E 1514/4885ALDH1A1 582/4885HPGD 170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.