Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9269460 | 0.79 | ESR2 (0.47) | ALDH1A1MEN1KMT2ANOTUMTP53 | |
| SCHEMBL1154499 | 0.78 | MAPT (0.42) | RAB9ANPC1MEN1KMT2ANOTUM | |
| SCHEMBL4322903 | 0.78 | ENPP3 (0.42) | RAB9ANPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL346163 | 0.78 | NOTUM (0.42) | RAB9ANPC1MEN1KMT2ANOTUM | |
| SCHEMBL4317407 | 0.78 | KIF11 (0.45) | RAB9ANPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL3283855 | 0.74 | NPC1 (0.46) | RAB9ANPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL9662582 | 0.74 | KIF11 (0.44) | RAB9ANPC1ALDH1A1NOTUMTSHR | |
| SCHEMBL2122676 | 0.69 | IDO1 (0.42) | RAB9ANPC1MEN1KMT2ANOTUM | |
| SCHEMBL3937636 | 0.69 | AHR (0.48) | RAB9ANPC1NOTUMTP53SMN1; SMN2 | |
| SCHEMBL730687 | 0.68 | RAB9A (0.45) | RAB9ANPC1ALDH1A1ALOX5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137380-A1 | 3-HYDRAZONE PIPERAZINYL RIFAMYCIN DERIVATIVES USEFUL AS ANTIMICROBIAL AGENTS | JANSSEN PHARMACEUTICA NV (BE) | 2009-11-12 | — | — | WO | claimed |
| US-20090275594-A1 | 3-HYDRAZONE PIPERAZINYL RIFAMYCIN DERIVATIVES USEFUL AS ANTIMICROBIAL AGENTS | JANSSEN PHARMACEUTICA NV (BE) | 2009-11-05 | — | — | US | claimed |
| US-20170073339-A1 | PYRIDINE DERIVATIVES | ENDO PHARMACEUTICALS, INC. | 2017-03-16 | — | — | US | disclosed |
| US-9371316-B2 | Pyridine derivatives | ASANA BIOSCIENCES, LLC (US) | 2016-06-21 | — | — | US | disclosed |
| US-20140364462-A1 | PYRIDINE DERIVATIVES | ASANA BIOSCIENCES, LLC | 2014-12-11 | — | — | US | disclosed |
| EP-2760833-A1 | PYRIDINE DERIVATIVES | Endo Pharmaceuticals Inc. (US) | 2014-08-06 | — | — | EP | disclosed |
| US-8486954-B2 | Heterobicyclic carboxamides as inhibitors for kinases | NOVARTIS AG (CH) | 2013-07-16 | — | — | US | disclosed |
| WO-2013049559-A1 | PYRIDINE DERIVATIVES | ENDO PHARMACEUTICALS INC. (US) | 2013-04-04 | — | — | WO | disclosed |
| US-20130005751-A1 | HETEROBICYCLIC CARBOXAMIDES AS INHIBITORS FOR KINASES | NOVARTIS AG (CH) | 2013-01-03 | — | — | US | disclosed |
| WO-2009137380-A1 | 3-HYDRAZONE PIPERAZINYL RIFAMYCIN DERIVATIVES USEFUL AS ANTIMICROBIAL AGENTS | JANSSEN PHARMACEUTICA NV (BE) | 2009-11-12 | — | — | WO | disclosed |
| US-20090275594-A1 | 3-HYDRAZONE PIPERAZINYL RIFAMYCIN DERIVATIVES USEFUL AS ANTIMICROBIAL AGENTS | JANSSEN PHARMACEUTICA NV (BE) | 2009-11-05 | — | — | US | disclosed |
| EP-2056844-A2 | NOVEL MACROLIDES AND KETOLIDES HAVING ANTIMICROBIAL ACTIVITY | Wockhardt Research Centre (IN) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008023248-A2 | NOVEL MACROLIDES AND KETOLIDES HAVING ANTIMICROBIAL ACTIVITY | WOCKHARDT RESEARCH CENTRE (IN) | 2008-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170073339-A1 | PYRIDINE DERIVATIVES | CYP21A2, CYP26A1, CYP11B1 | RAB9A 3120/4885NPC1 2391/4885ALDH1A1 87/4885 |
| US-20140364462-A1 | PYRIDINE DERIVATIVES | CYP21A2, CYP26A1, CYP11B1 | RAB9A 3120/4885NPC1 2391/4885ALDH1A1 87/4885 |
| US-20130005751-A1 | HETEROBICYCLIC CARBOXAMIDES AS INHIBITORS FOR KINASES | CDK2, PHKG1, PHKG2 | RAB9A 2155/4885NPC1 4183/4885ALDH1A1 3736/4885 |
| US-20090275594-A1 | 3-HYDRAZONE PIPERAZINYL RIFAMYCIN DERIVATIVES USEFUL AS ANTIMICROBIAL AGENTS | RIF1, ABCC1, HDAC6 | RAB9A 588/4885NPC1 202/4885ALDH1A1 1070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.