Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.63 |
| ▸ | RAB9A | P51151 | 5/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15499975 | 1.00 | NPC1 (0.63) | NPC1RAB9AHDAC3CA12CA1 | |
| SCHEMBL9539569 | 1.00 | NPC1 (0.63) | NPC1RAB9AHDAC3CA12CA1 | |
| SCHEMBL289886 | 0.83 | NPC1 (0.57) | NPC1RAB9AHDAC3CA12CA1 | |
| SCHEMBL23325380 | 0.82 | NPC1 (0.53) | NPC1RAB9AHDAC3CA12CA1 | |
| SCHEMBL5912481 | 0.79 | NPC1 (0.63) | NPC1RAB9AHDAC3CA12CA1 | |
| SCHEMBL11145084 | 0.79 | NPC1 (0.63) | NPC1RAB9AHDAC3CA12CA1 | |
| SCHEMBL11145105 | 0.79 | NPC1 (0.63) | NPC1RAB9AHDAC3CA12CA1 | |
| SCHEMBL6551872 | 0.79 | RAB9A (0.58) | NPC1RAB9AHDAC3CA12CA1 | |
| SCHEMBL17188462 | 0.79 | RAB9A (0.58) | NPC1RAB9AHDAC3CA12CA1 | |
| SCHEMBL13778457 | 0.79 | RAB9A (0.58) | NPC1RAB9AHDAC3CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993014086-A1 | SUBSTITUTED 1-ISOQUINOLONE DERIVATIVES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-07-22 | — | — | WO | claimed |
| CN-118653158-A | Synthesis and application of 4-oxo-oxazoline compound | 西北师范大学 | 2024-09-17 | — | — | CN | disclosed |
| US-7482449-B2 | Process for making spirolactone compounds | MERCK & CO., INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-20080171888-A1 | Process for making spirolactone compounds | MERCK SHARP & DOHME CORP. | 2008-07-17 | — | — | US | disclosed |
| US-7368569-B2 | Process for making spirolactone compounds | MERCK & CO., INC. (US) | 2008-05-06 | — | — | US | disclosed |
| US-20060241299-A1 | Process for making spirolactone compounds | VOLANTE RALPH P | 2006-10-26 | — | — | US | disclosed |
| US-20060014950-A1 | Process for Making Spirolactone Compounds | MERCK SHARP & DOHME CORP. | 2006-01-19 | — | — | US | disclosed |
| EP-1558605-A2 | PROCESS FOR MAKING SPIROLACTONE COMPOUNDS | Merck & Co., Inc. (US) | 2005-08-03 | — | — | EP | disclosed |
| EP-1048457-B1 | Lithographic printing plate precursor | FUJI PHOTO FILM CO LTD (JP) | 2004-12-15 | — | — | EP | disclosed |
| WO-2004104009-A1 | PROCESS FOR MAKING SPIROLACTONE COMPOUNDS | MERCK & CO., INC. (US) | 2004-12-02 | — | — | WO | disclosed |
| WO-2004037170-A2 | PROCESS FOR MAKING SPIROLACTONE COMPOUNDS | MERCK & CO., INC. (US) | 2004-05-06 | — | — | WO | disclosed |
| US-6455224-B1 | SUPPORT WITH HYDROPHILIC SURFACE AND PHOTOSENSITIVE LAYER CONTAINING INFRARED ABSORBENT WHICH CHANGES FROM HYDROPHILIC TO HYDROPHOBIC BY HEAT AND HYDROPHILIC POLYMER HAVING FUNCTIONAL GROUP RENDERING LAYER WATER DEVELOPABLE | FUJI PHOTO FILM CO., LTD. (JP) | 2002-09-24 | — | — | US | disclosed |
| EP-1048457-A2 | Lithographic printing plate precursor | FUJI PHOTO FILM CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |
| WO-1993014086-A1 | SUBSTITUTED 1-ISOQUINOLONE DERIVATIVES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-07-22 | — | — | WO | disclosed |
| US-4410530-A | CARDIO-SELECTIVE B-RECEPTOR BLOCKING AGENTS AND STIMULANTS | CIBA-GEIGY CORPORATION (US) | 1983-10-18 | — | — | US | disclosed |
| US-4203896-A | WITH MERCURIC ACETATE AND ACETIC ACID, ACIDIC HYDROLYSIS OF N-PROPENYL GROUP | ELI LILLY AND COMPANY (US) | 1980-05-20 | — | — | US | disclosed |
| US-4195090-A | ADRENERGIC BLOCKING AGENTS | CIBA-GEIGY CORPORATION (US) | 1980-03-25 | — | — | US | disclosed |
| US-4144232-A | Substituted azetidin-2-one antibiotics | ELI LILLY AND COMPANY (US) | 1979-03-13 | — | — | US | disclosed |
| US-4115575-A | CARDIOVASCULAR DISORDERS | CIBA-GEIGY CORPORATION (US) | 1978-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241299-A1 | Process for making spirolactone compounds | HSD17B7, SDHB, SDHA | NPC1 2071/4885RAB9A 2529/4885HDAC3 2951/4885 |
| US-20080171888-A1 | Process for making spirolactone compounds | HSD17B7, CYP17A1, REN | NPC1 995/4885RAB9A 3140/4885HDAC3 1986/4885 |
| US-20060014950-A1 | Process for Making Spirolactone Compounds | HSD17B7, CYP17A1, REN | NPC1 995/4885RAB9A 3140/4885HDAC3 1986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.