SCHEMBL4310302

SCHEMBL4310302

CCOC1[C]=CCc2ccccc21

nearest known ligand 0.36

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 8/20 0.33
ALDH1A1 P00352 2/20 0.33
HTR2C P28335 2/20 0.33
HTR2B P41595 1/20 0.33
NPC1 O15118 1/20 0.33
TP53 P04637 1/20 0.33
MAPT P10636 1/20 0.33
RAB9A P51151 1/20 0.33
BACE1 P56817 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HRH1 P35367 5/20 0.32
SLC6A2 P23975 2/20 0.32
RET P07949 1/20 0.31
SLC6A4 P31645 1/20 0.31
SLC6A3 Q01959 1/20 0.31
PRCP P42785 1/20 0.30
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4310550 0.82 MAPT (0.32) HTR2AMAPTHRH1MEN1KMT2A
SCHEMBL9199555 0.82 MAPT (0.32) HTR2AMAPTHRH1MEN1KMT2A
SCHEMBL1009380 0.80 HTR2A (0.38) HTR2AHTR2CHRH1RET
SCHEMBL9198328 0.80 CTSL (0.40) HTR2ASLC6A2SLC6A4SLC6A3PRCP
SCHEMBL8492145 0.78 PDPK1 (0.32) MAPT
SCHEMBL455641 0.75 HTR2A (0.34) HTR2AHTR2CHRH1RETPRCP
SCHEMBL8890669 0.73 CHRNB2 (0.33) HTR2A
SCHEMBL458495 0.72 HTR2A (0.35) HTR2AALDH1A1HTR2CHTR2BMAPT
SCHEMBL4290508 0.72 HTR2A (0.35) HTR2AALDH1A1HTR2CHTR2BMAPT
SCHEMBL6521360 0.72 HTR2A (0.35) HTR2AALDH1A1HTR2CHTR2BMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3464292-A1 MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF DISORDERS RELATED THERETO Arena Pharmaceuticals, Inc. (US) 2019-04-10 EP disclosed
WO-2017214002-A1 MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2017-12-14 WO disclosed
WO-2009136965-A1 COMPOSITIONS AND METHODS COMPRISING CAPURAMYCIN ANALOGUES SEQUELLA, INC. (US) 2009-11-12 WO disclosed