Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDYL2 | Q8N8U2 | 4/20 | 0.52 |
| ▸ | CDYL | Q9Y232 | 4/20 | 0.52 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | CBX7 | O95931 | 2/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4306365 | 0.85 | LMNA (0.45) | POLBHPGDKDM4EMEN1KMT2A | |
| SCHEMBL4301494 | 0.85 | MRGPRX4 (0.44) | NPC1RAB9ASMN1; SMN2POLBESR1 | |
| SCHEMBL4302800 | 0.85 | CDYL2 (0.49) | CDYL2CDYLCDY1; CDY1BNPC1RAB9A | |
| SCHEMBL4307512 | 0.84 | CDYL2 (0.48) | CDYL2CDYLCDY1; CDY1BNPC1RAB9A | |
| SCHEMBL8022961 | 0.80 | NPC1 (0.45) | CDYL2CDYLCDY1; CDY1BNPC1RAB9A | |
| SCHEMBL4306740 | 0.77 | KMT2A (0.59) | POLBESR1MAPTKDM4EMEN1 | |
| SCHEMBL4305020 | 0.76 | LMNA (0.46) | MAPTHPGDKDM4EMEN1KMT2A | |
| SCHEMBL8015699 | 0.74 | PKM (0.44) | NPC1RAB9ASMN1; SMN2POLBESR1 | |
| SCHEMBL11248287 | 0.73 | CES2 (0.69) | NPC1RAB9ASMN1; SMN2POLBBLM | |
| SCHEMBL30758862 | 0.73 | CES2 (0.69) | NPC1RAB9ASMN1; SMN2POLBBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009130231-A1 | PYRROLO [1, 2-A] PYRAZINE DERIVATIVES AS VASOPRESSIN VIB RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |
| WO-2009130231-A1 | PYRROLO [1, 2-A] PYRAZINE DERIVATIVES AS VASOPRESSIN VIB RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | WO | disclosed |