Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRC | P08575 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.48 |
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.46 |
| ▸ | MAOB | P27338 | 4/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 2/20 | 0.44 |
| ▸ | RXRB | P28702 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6334189 | 0.99 | F2 (0.48) | PTPRCPTPN1MRGPRX4F2NR4A2 | |
| Amelubant SCHEMBL1891670 | 0.90 | GRM5 (0.45) | PTPRCPTPN1MRGPRX4F2NR4A2 | |
| Amelubant SCHEMBL29359085 | 0.90 | GRM5 (0.45) | PTPRCPTPN1MRGPRX4F2NR4A2 | |
| SCHEMBL5200582 | 0.85 | PTPRC (0.46) | PTPRCPTPN1MRGPRX4F2NR4A2 | |
| SCHEMBL31506335 | 0.82 | F2 (0.72) | F2 | |
| SCHEMBL4999957 | 0.82 | F2 (0.72) | F2 | |
| Hydrochloric Acid SCHEMBL6557386 | 0.81 | F2 (0.73) | F2 | |
| SCHEMBL668003 | 0.80 | PTPRC (0.46) | PTPRCPTPN1MRGPRX4F2NR4A2 | |
| SCHEMBL22120093 | 0.80 | NR4A1 (0.64) | PTPRCPTPN1NR4A2MAOBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7631983 | 0.79 | F2 (0.46) | PTPRCPTPN1MRGPRX4F2NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417382-B1 | — | — | None | — | — | US | disclosed |
| US-10220165-B2 | Inhalator and capsule for an inhalator | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-03-05 | — | — | US | disclosed |
| EP-2875020-B1 | PROCESS FOR THE PREPARATION OF A FUMARIC ACID SALT OF 9-[4-(3-CHLORO-2-FLUORO-PHENYLAMINO)-7-METHOXY- CHINAZOLIN-6-YLOXY]-1,4-DIAZA-SPIRO[5.5]UNDECAN-5-ONE | BOEHRINGER INGELHEIM INT (DE) | 2017-09-06 | — | — | EP | disclosed |
| EP-2875020-A1 | FUMARIC ACID SALT OF 9-[4-(3-CHLORO-2-FLUORO-PHENYLAMINO)-7-METHOXY- CHINAZOLIN-6-YLOXY]-1,4-DIAZA-SPIRO[5.5]UNDECAN-5-ONE, ITS USE AS MEDICAMENT AND THE PREPARATION THEREOF | Boehringer Ingelheim International GmbH (DE) | 2015-05-27 | — | — | EP | disclosed |
| US-8906931-B1 | 9-[4-(3-chloro-2-fluoro-phenylamino-7-methoxy-quinazoline-6-yloxy]-1,4-diaza-spiro[5.5]undecane-5-one dimaleate, use thereof as a medicament and method for the production thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-12-09 | — | — | US | disclosed |
| US-8772298-B2 | Spirocyclic heterocycles medicaments containing said compounds, use thereof and method for their production | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-07-08 | — | — | US | disclosed |
| US-20140182587-A1 | INHALATOR AND CAPSULE FOR AN INHALATOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-07-03 | — | — | US | disclosed |
| WO-2014012859-A1 | FUMARIC ACID SALT OF 9-[4-(3-CHLORO-2-FLUORO-PHENYLAMINO)-7-METHOXY- CHINAZOLIN-6-YLOXY]-1,4-DIAZA-SPIRO[5.5]UNDECAN-5-ONE, ITS USE AS MEDICAMENT AND THE PREPARATION THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-23 | — | — | WO | disclosed |
| US-8598359-B2 | Biaryl substituted heterocycle inhibitors of LTA4H for treating inflammation | DECODE GENETICS EHF (IS) | 2013-12-03 | — | — | US | disclosed |
| US-20130281461-A1 | Spirocyclic Heterocycles Medicaments Containing Said Compounds, Use Thereof And Method For Their Production | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-10-24 | — | — | US | disclosed |
| US-20110046148-A1 | Spirocyclic Heterocycles Medicaments Containing Said Compounds, Use Thereof And Method For Their Production | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-02-24 | — | — | US | disclosed |
| US-20090163462-A1 | BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS, EHF (IS) | 2009-06-25 | — | — | US | disclosed |
| US-20080260817-A1 | Compositions for the Treatment of Inflammation and Pain Using a Combination of a Cox-2 Selective Inhibitor and a Ltb4 Receptor Antagonist | PFIZER INC. | 2008-10-23 | — | — | US | disclosed |
| US-7402684-B2 | Biaryl substituted heterocycle inhibitors of LTA4H for treating inflammation | DECODE GENECTICS EHF. (IS) | 2008-07-22 | — | — | US | disclosed |
| US-20070078263-A1 | BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE CHEMISTRY, INC. (US) | 2007-04-05 | — | — | US | disclosed |
| US-20070066820-A1 | BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE CHEMISTRY, INC. (US) | 2007-03-22 | — | — | US | disclosed |
| US-6861547-B2 | Process for preparing aryl-iminomethyl-carbamino acid esters | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-03-01 | — | — | US | disclosed |
| US-20020137963-A1 | Process for preparing aryl-iminomethyl-carbamino acid esters | BRANDENBURG JOERG (DE) | 2002-09-26 | — | — | US | disclosed |
| US-6417382-B2 | REACTING 4-((3-(PHENOXYMETHYL)PHENOXYMETHYL)BENZONITRILE WITH AN ALKALI METAL HEXAALKYLDISILAZANE AND TREATING THE RESULTING COMPOUND WITH A CARBONATE OR HALOFORMATE, FORMING A PROTIC ACID SALT, ISOLATING THE SALT AND TREATING WITH BASE | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-07-09 | — | — | US | disclosed |
| US-20010009958-A1 | Process for preparing aryl-iminomethyl-carbamino acid esters | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2001-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046148-A1 | Spirocyclic Heterocycles Medicaments Containing Said Compounds, Use Thereof And Method For Their Production | PKD1, BPHL, CYP11B2 | PTPRC 512/4885PTPN1 621/4885MRGPRX4 2590/4885 |
| US-20020137963-A1 | Process for preparing aryl-iminomethyl-carbamino acid esters | MEP1A, CPS1, CYP51A1 | PTPRC 2831/4885PTPN1 2997/4885MRGPRX4 2377/4885 |
| US-20130281461-A1 | Spirocyclic Heterocycles Medicaments Containing Said Compounds, Use Thereof And Method For Their Production | PKD1, BPHL, CYP11B2 | PTPRC 512/4885PTPN1 621/4885MRGPRX4 2590/4885 |
| US-20090163462-A1 | BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | LTA4H, LTB4R, LTC4S | PTPRC 2191/4885PTPN1 3917/4885MRGPRX4 174/4885 |
| US-20010009958-A1 | Process for preparing aryl-iminomethyl-carbamino acid esters | MEP1A, CPS1, CYP51A1 | PTPRC 2831/4885PTPN1 2997/4885MRGPRX4 2377/4885 |
| US-20070066820-A1 | BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | LTA4H, LTB4R, LTC4S | PTPRC 2191/4885PTPN1 3917/4885MRGPRX4 174/4885 |
| US-20070078263-A1 | BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | LTA4H, LTB4R, LTC4S | PTPRC 2191/4885PTPN1 3917/4885MRGPRX4 174/4885 |
| US-20080260817-A1 | Compositions for the Treatment of Inflammation and Pain Using a Combination of a Cox-2 Selective Inhibitor and a Ltb4 Receptor Antagonist | LTB4R2, LTB4R, LTC4S | PTPRC 1491/4885PTPN1 2736/4885MRGPRX4 111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.