Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Prednisolone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 14/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.71 |
| ▸ | PGR | P06401 | 4/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.71 |
| ▸ | TNF | P01375 | 1/20 | 0.71 |
| ▸ | IL6 | P05231 | 1/20 | 0.71 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.71 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.71 |
| ▸ | AR | P10275 | 1/20 | 0.71 |
| ▸ | GLUL | P15104 | 1/20 | 0.71 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.71 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prednisolone SCHEMBL5013652 | 1.00 | NR3C1 (0.71) | NR3C1HIF1APGRHSD17B10CYP3A4 | |
| SCHEMBL11332832 | 0.89 | HIF1A (0.65) | NR3C1HIF1APGRHSD17B10CYP3A4 | |
| Prednisolone Metazoate SCHEMBL2916561 | 0.87 | PGR (0.70) | NR3C1HIF1APGRHSD17B10CYP3A4 | |
| Prednisolone Metazoate SCHEMBL5483006 | 0.87 | PGR (0.69) | NR3C1HIF1APGRHSD17B10CYP3A4 | |
| Prednisolone SCHEMBL1803461 | 0.86 | NR3C1 (0.90) | NR3C1HIF1APGRHSD17B10CYP3A4 | |
| Prednisolone SCHEMBL5524347 | 0.86 | NR3C1 (0.93) | NR3C1HIF1APGRHSD17B10CYP3A4 | |
| Prednisolone SCHEMBL29053219 | 0.85 | NR3C1 (0.80) | NR3C1HIF1APGRHSD17B10CYP3A4 | |
| Prednisolone SCHEMBL28451307 | 0.85 | NR3C1 (0.91) | NR3C1HIF1APGRHSD17B10CYP3A4 | |
| Prednisolone SCHEMBL1803463 | 0.85 | NR3C1 (0.91) | NR3C1HIF1APGRHSD17B10CYP3A4 | |
| Prednisolone SCHEMBL29170842 | 0.85 | NR3C1 (0.79) | NR3C1HIF1APGRHSD17B10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10877035-B2 | Advanced drug development and manufacturing | ICAGEN, LLC (US) | 2020-12-29 | — | — | US | disclosed |
| US-20150309021-A1 | Advanced Drug Development and Manufacturing | LOS ALAMOS NATIONAL SECURITY, LLC | 2015-10-29 | — | — | US | disclosed |
| EP-2511844-B1 | X-ray microscope | XRPRO SCIENCES INC (US) | 2015-08-12 | — | — | EP | disclosed |
| EP-2511844-A2 | Advanced drug development and manufacturing | Los Alamos National Security, LLC (US) | 2012-10-17 | — | — | EP | disclosed |
| EP-2084519-B1 | X-RAY FLUORESCENCE ANALYSIS METHOD | LOS ALAMOS NAT SECURITY LLC (US) | 2012-08-01 | — | — | EP | disclosed |
| EP-2084519-A2 | ADVANCED DRUG DEVELOPMENT AND MANUFACTURING | Los Alamos National Security, LLC (US) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008127291-A2 | ADVANCED DRUG DEVELOPMENT AND MANUFACTURING | LOS ALAMOS NATIONAL SECURITY, LLC (US) | 2008-10-23 | — | — | WO | disclosed |
| US-20080220441-A1 | Advanced drug development and manufacturing | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2008-09-11 | — | — | US | disclosed |