Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1518274 | 0.84 | POLB (0.71) | POLBTDP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL5820805 | 0.82 | ALDH1A1 (0.64) | POLBTDP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL56944 | 0.82 | ALDH1A1 (0.74) | POLBTDP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL379309 | 0.81 | ALDH1A1 (0.62) | POLBTDP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL30512327 | 0.81 | ALDH1A1 (0.62) | POLBTDP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL8265051 | 0.81 | ALDH1A1 (0.69) | POLBTDP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL5475563 | 0.79 | ALDH1A1 (0.76) | POLBALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL14448832 | 0.79 | POLB (0.62) | POLBTDP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL31516344 | 0.79 | POLB (0.62) | POLBTDP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL23538115 | 0.79 | POLB (0.52) | POLBTDP1L3MBTL1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200323829-A1 | Inhibitors of Mitochondrial Fission | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2020-10-15 | — | — | US | disclosed |
| CN-100522944-C | Carboxylic acid derivatives and salts thereof | EISAI CO LTD (JP) | 2009-08-05 | — | — | CN | disclosed |
| US-7544835-B2 | Carboxylic acid derivative and salt thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-09 | — | — | US | disclosed |
| US-7544835-B2 | Carboxylic acid derivative and salt thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-09 | — | — | US | disclosed |
| US-7544835-B2 | Carboxylic acid derivative and salt thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-09 | — | — | US | disclosed |
| CN-1503774-A | Carboxylic acid derivatives and salts thereof | ������������ʽ���� | 2004-06-09 | — | — | CN | disclosed |
| US-20040102634-A1 | Carboxylic acid derivative and salt thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2004-05-27 | — | — | US | disclosed |
| EP-1380562-A1 | CARBOXYLIC ACID DERIVATIVE AND SALT THEREOF | Eisai Co., Ltd. (JP) | 2004-01-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102634-A1 | Carboxylic acid derivative and salt thereof | GPR119, IRS1, SLC5A1 | POLB 3622/4885TDP1 4437/4885L3MBTL1 3856/4885 |
| US-20200323829-A1 | Inhibitors of Mitochondrial Fission | FIS1, DNM1L, RHOT2 | POLB 960/4885TDP1 727/4885L3MBTL1 2353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.