Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | LIPE | Q05469 | 1/20 | 0.31 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.31 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4331969 | 1.00 | CTSK (0.36) | CTSKKMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL28339421 | 0.86 | USP30 (0.38) | ALDH1A1NPC1LMNA | |
| SCHEMBL8539792 | 0.80 | SMN1; SMN2 (0.40) | KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL10520052 | 0.80 | NPSR1 (0.39) | ALDH1A1MAPTNPC1 | |
| SCHEMBL1643846 | 0.76 | SLC6A2 (0.39) | HPGDALDH1A1MAPTBCL2A1NPC1 | |
| SCHEMBL7447861 | 0.74 | MEN1 (0.40) | CTSKKMT2AMEN1ALDH1A1 | |
| SCHEMBL3989548 | 0.72 | KMT2A (0.40) | CTSKKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL2791434 | 0.72 | SMN1; SMN2 (0.39) | CTSKKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL2791431 | 0.72 | SMN1; SMN2 (0.39) | CTSKKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL4324062 | 0.71 | TRPM8 (0.40) | CTSKHPGDALDH1A1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102169-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | AstraZeneca AB (SE) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008076048-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |