Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4324066 | 1.00 | TRPM8 (0.40) | TRPM8MAPTRAB9ALMNANPC1 | |
| SCHEMBL2791434 | 0.84 | SMN1; SMN2 (0.39) | MAPTRAB9ALMNANPC1SMN1; SMN2 | |
| SCHEMBL2791431 | 0.84 | SMN1; SMN2 (0.39) | MAPTRAB9ALMNANPC1SMN1; SMN2 | |
| SCHEMBL3989548 | 0.84 | KMT2A (0.40) | MAPTLMNATSHRNPSR1ALDH1A1 | |
| SCHEMBL8539792 | 0.84 | SMN1; SMN2 (0.40) | TRPM8RAB9ALMNASMN1; SMN2CYP1A2 | |
| SCHEMBL4381548 | 0.82 | GPR119 (0.35) | MAPTKDM4ENOX1ALDH1A1TAS1R3 | |
| SCHEMBL4381546 | 0.82 | GPR119 (0.35) | MAPTKDM4ENOX1ALDH1A1TAS1R3 | |
| SCHEMBL10431533 | 0.82 | KEAP1 (0.42) | TRPM8MAPTRAB9ALMNANPC1 | |
| SCHEMBL4326713 | 0.81 | TRPM8 (0.48) | TRPM8MAPTRAB9ALMNANPC1 | |
| SCHEMBL7630006 | 0.80 | ALOX5 (0.47) | LMNAALOX5L3MBTL1NOX1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102169-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | AstraZeneca AB (SE) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008076048-A1 | INDAZOLYL ESTER AND AMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |