Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | GHSR | Q92847 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4338523 | 0.81 | POLB (0.49) | ALDH1A1GAAGHSRPOLBHPGD | |
| SCHEMBL2001631 | 0.79 | ALDH1A1 (0.44) | ALDH1A1GAAPOLBLMNARAB9A | |
| SCHEMBL13283814 | 0.75 | HTT (0.47) | ALDH1A1GAAPOLBLMNATSHR | |
| SCHEMBL4339455 | 0.72 | NR1H4 (0.48) | — | |
| SCHEMBL4336583 | 0.70 | KMT2A (0.41) | ALDH1A1GAAGHSRLMNARAB9A | |
| SCHEMBL5776232 | 0.69 | HPGD (0.44) | ALDH1A1GAAGHSRPOLBLMNA | |
| SCHEMBL16726632 | 0.69 | CA12 (0.44) | ALDH1A1TSHRMAPK1HPGD | |
| SCHEMBL31368236 | 0.69 | CA12 (0.44) | ALDH1A1TSHRMAPK1HPGD | |
| SCHEMBL4336590 | 0.69 | LMNA (0.44) | ALDH1A1GAAGHSRPOLBLMNA | |
| SCHEMBL3637232 | 0.68 | GPBAR1 (0.43) | ALDH1A1GHSRPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079307-A2 | FARNESOID X RECEPTOR AGONISTS | SmithKline Beecham Corporation (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008051942-A2 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-05-02 | — | — | WO | disclosed |