Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | GHSR | Q92847 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4332205 | 0.81 | ALDH1A1 (0.43) | POLBGHSRALDH1A1GAAHPGD | |
| SCHEMBL1999474 | 0.79 | POLB (0.51) | POLBGHSRALDH1A1GAAMAPT | |
| SCHEMBL4332237 | 0.77 | GHSR (0.38) | GHSRGPBAR1NR1H4 | |
| SCHEMBL5772850 | 0.73 | ALDH1A1 (0.53) | POLBGHSRALDH1A1GAAMAPT | |
| SCHEMBL4010252 | 0.72 | POLB (0.68) | POLBGHSRALDH1A1GAAMAPT | |
| SCHEMBL4332248 | 0.72 | NR1H4 (0.54) | NR1H4 | |
| SCHEMBL6081703 | 0.72 | GHSR (0.62) | POLBGHSRALDH1A1GAAMAPT | |
| SCHEMBL4946160 | 0.70 | POLB (0.45) | POLBGHSRALDH1A1GAAMAPT | |
| SCHEMBL4951120 | 0.70 | POLB (0.45) | POLBGHSRALDH1A1GAAMAPT | |
| SCHEMBL30227922 | 0.70 | ATR (0.46) | POLBALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079307-A2 | FARNESOID X RECEPTOR AGONISTS | SmithKline Beecham Corporation (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008051942-A2 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-05-02 | — | — | WO | disclosed |