SCHEMBL433238

SCHEMBL433238

COC(=O)c1ccc(N=C2C=CC3=C(C2)Sc2cc(C(C)=O)ccc2N3)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 5/20 0.41
▸ ALOX15 P16050 4/20 0.41
▸ MEN1 O00255 3/20 0.41
▸ KMT2A Q03164 3/20 0.41
▸ MAPK1 P28482 2/20 0.41
▸ HSD17B10 Q99714 2/20 0.41
▸ HTT P42858 2/20 0.41
▸ FGB P02675 1/20 0.41
▸ HSP90AA1 P07900 1/20 0.41
▸ HSP90AB1 P08238 1/20 0.41
▸ HPGD P15428 1/20 0.41
▸ CYBB P04839 1/20 0.37
▸ APP P05067 1/20 0.37
▸ GAA P10253 1/20 0.37
▸ SNCA P37840 1/20 0.37
▸ NOX3 Q9HBY0 1/20 0.37
▸ NOX4 Q9NPH5 1/20 0.37
▸ NOX1 Q9Y5S8 1/20 0.37
▸ LMNA P02545 3/20 0.35
▸ ALDH1A1 P00352 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL433397 0.88 MAPT (0.41) MAPTALOX15MEN1KMT2AMAPK1
SCHEMBL436033 0.74 NOX1 (0.41) MAPTALOX15MEN1KMT2AMAPK1
SCHEMBL434466 0.71 MAPT (0.46) MAPTALOX15MEN1KMT2AMAPK1
SCHEMBL436040 0.69 NOX1 (0.38) MAPTALOX15MEN1KMT2AMAPK1
SCHEMBL433635 0.69 MAPT (0.39) MAPTALOX15MEN1KMT2AMAPK1
SCHEMBL563959 0.68 GAA (0.42) MAPTALOX15MEN1KMT2AMAPK1
SCHEMBL435356 0.64 NOX1 (0.35) MAPTALOX15MEN1KMT2AMAPK1
SCHEMBL432486 0.64 MEN1 (0.45) MAPTALOX15MEN1KMT2AMAPK1
SCHEMBL12311060 0.64 NOX1 (0.82) MAPTALOX15MEN1KMT2AMAPK1
SCHEMBL10591060 0.62 SNCA (0.55) MAPTMEN1KMT2AMAPK1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11851685-B2 Zwitterion buffer containing compositions and uses in electroanalytical devices and methods ROCHE DIABETES CARE, INC. (US) 2023-12-26 — — US claimed
EP-1867732-A1 Reagents, methods and devices for detecting analytes Bayer Corporation (US) 2007-12-19 — — EP claimed
EP-1293574-B1 Reagents, methods and devices for detecting analytes BAYER CORP (US) 2007-11-21 — — EP claimed
US-7163616-B2 Reagents and methods for detecting analytes, and devices comprising reagents for detecting analytes BAYER CORPORATION (US) 2007-01-16 — — US claimed
US-20030094384-A1 Reagents and methods for detecting analytes, and devices comprising reagents for detecting analytes ASCENSIA DIABETES CARE HOLDINGS AG (CH) 2003-05-22 — — US claimed
EP-1293574-A2 Reagents, methods and devices for detecting analytes Bayer Corporation (US) 2003-03-19 — — EP claimed
EP-0747984-B1 Mediators suitable for the electrochemical regeneration of NADH, NADPH or analogs thereof BAYER AG (US) 2002-08-14 — — EP claimed
EP-0747984-A2 Mediators suitable for the electrochemical regeneration of NADH, NADPH or analogs thereof Bayer Corporation (US) 1996-12-11 — — EP claimed
US-5520786-A ELECTRODE SURFACE HAS BEEN IMPARTED BY A MEDIATOR FUNCTION COMPRISING ONE OR MORE MEDIATOR COMPOUNDS SELECTED FROM SUBSTITUTED OR UNSUBSTITUTED 3-PHENYLIMINO-3H-PHENOTHIAZINES AND 3-PHENYLIMINO-3H-PHENOXAZINES BAYER CORPORATION (US) 1996-05-28 — — US claimed
US-11851685-B2 Zwitterion buffer containing compositions and uses in electroanalytical devices and methods ROCHE DIABETES CARE, INC. (US) 2023-12-26 — — US disclosed
US-20220275348-A1 ZWITTERION BUFFER CONTAINING COMPOSITIONS AND USES IN ELECTROANALYTICAL DEVICES AND METHODS ROCHE DIABETES CARE, INC. 2022-09-01 — — US disclosed
US-11180790-B2 Reagents and methods for detecting analytes ASCENSIA DIABETES CARE HOLDINGS AG (CH) 2021-11-23 — — US disclosed
EP-3388824-B1 METHODS OF DETECTING HIGH ANTIOXIDANT LEVELS DURING ELECTROCHEMICAL MEASUREMENTS AND FAILSAFING AN ANALYTE CONCENTRATION THEREFROM AS WELL AS DEVICES AND SYSTEMS INCORPORTING THE SAME ROCHE DIABETES CARE GMBH (DE) 2021-04-14 — — EP disclosed
US-20200270668-A1 REAGENTS AND METHODS FOR DETECTING ANALYTES BAYER HEALTHCARE, LLC 2020-08-27 — — US disclosed
US-7163616-B2 Reagents and methods for detecting analytes, and devices comprising reagents for detecting analytes BAYER CORPORATION (US) 2007-01-16 — — US disclosed
US-20030094384-A1 Reagents and methods for detecting analytes, and devices comprising reagents for detecting analytes ASCENSIA DIABETES CARE HOLDINGS AG (CH) 2003-05-22 — — US disclosed
EP-1293574-A2 Reagents, methods and devices for detecting analytes Bayer Corporation (US) 2003-03-19 — — EP disclosed
EP-0747984-B1 Mediators suitable for the electrochemical regeneration of NADH, NADPH or analogs thereof BAYER AG (US) 2002-08-14 — — EP disclosed
EP-0747984-A2 Mediators suitable for the electrochemical regeneration of NADH, NADPH or analogs thereof Bayer Corporation (US) 1996-12-11 — — EP disclosed
US-5520786-A ELECTRODE SURFACE HAS BEEN IMPARTED BY A MEDIATOR FUNCTION COMPRISING ONE OR MORE MEDIATOR COMPOUNDS SELECTED FROM SUBSTITUTED OR UNSUBSTITUTED 3-PHENYLIMINO-3H-PHENOTHIAZINES AND 3-PHENYLIMINO-3H-PHENOXAZINES BAYER CORPORATION (US) 1996-05-28 — — US disclosed
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