SCHEMBL436040

SCHEMBL436040

O=C(O)c1cc(N=C2C=CC3=C(C2)Sc2ccccc2N3)cc(C(=O)O)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NOX1 Q9Y5S8 8/20 0.38
▸ GAA P10253 8/20 0.37
▸ MAPT P10636 7/20 0.37
▸ MEN1 O00255 5/20 0.37
▸ KMT2A Q03164 5/20 0.37
▸ ALOX15 P16050 2/20 0.37
▸ SNCA P37840 2/20 0.37
▸ CYBB P04839 1/20 0.37
▸ APP P05067 1/20 0.37
▸ NOX3 Q9HBY0 1/20 0.37
▸ NOX4 Q9NPH5 1/20 0.37
▸ POLB P06746 4/20 0.36
▸ NPC1 O15118 4/20 0.36
▸ RAB9A P51151 4/20 0.36
▸ KDM4E B2RXH2 3/20 0.36
▸ L3MBTL1 Q9Y468 3/20 0.36
▸ MCL1 Q07820 2/20 0.36
▸ NPSR1 Q6W5P4 3/20 0.36
▸ GFER P55789 1/20 0.36
▸ MAOB P27338 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL563322 1.00 NOX1 (0.38) NOX1GAAMAPTMEN1KMT2A
SCHEMBL436033 0.89 NOX1 (0.41) NOX1GAAMAPTMEN1KMT2A
SCHEMBL563959 0.84 GAA (0.42) NOX1GAAMAPTMEN1KMT2A
SCHEMBL433397 0.79 MAPT (0.41) NOX1GAAMAPTMEN1KMT2A
SCHEMBL433232 0.77 NOX1 (0.42) NOX1GAAMAPTMEN1KMT2A
SCHEMBL10370002 0.76 GAA (0.48) NOX1GAAMAPTMEN1KMT2A
SCHEMBL434952 0.74 SNCA (0.48) NOX1GAAMAPTMEN1KMT2A
SCHEMBL435356 0.74 NOX1 (0.35) NOX1GAAMAPTMEN1KMT2A
SCHEMBL434961 0.74 NOX1 (0.46) NOX1GAAMAPTMEN1KMT2A
SCHEMBL434466 0.74 MAPT (0.46) NOX1GAAMAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11851685-B2 Zwitterion buffer containing compositions and uses in electroanalytical devices and methods ROCHE DIABETES CARE, INC. (US) 2023-12-26 — — US claimed
US-20150330935-A1 TEST DEVICE FOR ELECTROCHEMICAL ANALYSIS ALERE TECHNOLOGIES LIMITED (GB) 2015-11-19 — — US claimed
EP-2938602-A1 TEST DEVICE FOR ELECTROCHEMICAL ANALYSIS Alere Switzerland GmbH (CH) 2015-11-04 — — EP claimed
WO-2014096407-A1 TEST DEVICE FOR ELECTROCHEMICAL ANALYSIS ALERE SWITZERLAND GMBH (CH) 2014-06-26 — — WO claimed
EP-1867732-A1 Reagents, methods and devices for detecting analytes Bayer Corporation (US) 2007-12-19 — — EP claimed
EP-1293574-B1 Reagents, methods and devices for detecting analytes BAYER CORP (US) 2007-11-21 — — EP claimed
US-7163616-B2 Reagents and methods for detecting analytes, and devices comprising reagents for detecting analytes BAYER CORPORATION (US) 2007-01-16 — — US claimed
US-20030094384-A1 Reagents and methods for detecting analytes, and devices comprising reagents for detecting analytes ASCENSIA DIABETES CARE HOLDINGS AG (CH) 2003-05-22 — — US claimed
EP-1293574-A2 Reagents, methods and devices for detecting analytes Bayer Corporation (US) 2003-03-19 — — EP claimed
EP-0747984-B1 Mediators suitable for the electrochemical regeneration of NADH, NADPH or analogs thereof BAYER AG (US) 2002-08-14 — — EP claimed
EP-0747984-A2 Mediators suitable for the electrochemical regeneration of NADH, NADPH or analogs thereof Bayer Corporation (US) 1996-12-11 — — EP claimed
US-5520786-A ELECTRODE SURFACE HAS BEEN IMPARTED BY A MEDIATOR FUNCTION COMPRISING ONE OR MORE MEDIATOR COMPOUNDS SELECTED FROM SUBSTITUTED OR UNSUBSTITUTED 3-PHENYLIMINO-3H-PHENOTHIAZINES AND 3-PHENYLIMINO-3H-PHENOXAZINES BAYER CORPORATION (US) 1996-05-28 — — US claimed
US-11851685-B2 Zwitterion buffer containing compositions and uses in electroanalytical devices and methods ROCHE DIABETES CARE, INC. (US) 2023-12-26 — — US disclosed
US-20220275348-A1 ZWITTERION BUFFER CONTAINING COMPOSITIONS AND USES IN ELECTROANALYTICAL DEVICES AND METHODS ROCHE DIABETES CARE, INC. 2022-09-01 — — US disclosed
US-11180790-B2 Reagents and methods for detecting analytes ASCENSIA DIABETES CARE HOLDINGS AG (CH) 2021-11-23 — — US disclosed
EP-3388824-B1 METHODS OF DETECTING HIGH ANTIOXIDANT LEVELS DURING ELECTROCHEMICAL MEASUREMENTS AND FAILSAFING AN ANALYTE CONCENTRATION THEREFROM AS WELL AS DEVICES AND SYSTEMS INCORPORTING THE SAME ROCHE DIABETES CARE GMBH (DE) 2021-04-14 — — EP disclosed
EP-1293574-A2 Reagents, methods and devices for detecting analytes Bayer Corporation (US) 2003-03-19 — — EP disclosed
EP-0747984-B1 Mediators suitable for the electrochemical regeneration of NADH, NADPH or analogs thereof BAYER AG (US) 2002-08-14 — — EP disclosed
EP-0747984-A2 Mediators suitable for the electrochemical regeneration of NADH, NADPH or analogs thereof Bayer Corporation (US) 1996-12-11 — — EP disclosed
US-5520786-A ELECTRODE SURFACE HAS BEEN IMPARTED BY A MEDIATOR FUNCTION COMPRISING ONE OR MORE MEDIATOR COMPOUNDS SELECTED FROM SUBSTITUTED OR UNSUBSTITUTED 3-PHENYLIMINO-3H-PHENOTHIAZINES AND 3-PHENYLIMINO-3H-PHENOXAZINES BAYER CORPORATION (US) 1996-05-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150330935-A1 TEST DEVICE FOR ELECTROCHEMICAL ANALYSIS TES, FHIT, COXFA4L2 NOX1 1015/4885GAA 1534/4885MAPT 727/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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