SCHEMBL433397

SCHEMBL433397

COC(=O)c1ccc(N=C2C=CC3=C(C2)Sc2ccccc2N3)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 7/20 0.41
▸ RAB9A P51151 4/20 0.41
▸ L3MBTL1 Q9Y468 2/20 0.41
▸ CASP3 P42574 1/20 0.41
▸ SENP8 Q96LD8 1/20 0.41
▸ SENP7 Q9BQF6 1/20 0.41
▸ SENP6 Q9GZR1 1/20 0.41
▸ LMNA P02545 4/20 0.40
▸ PKM P14618 1/20 0.40
▸ GAA P10253 3/20 0.38
▸ MEN1 O00255 3/20 0.38
▸ KMT2A Q03164 3/20 0.38
▸ NOX1 Q9Y5S8 2/20 0.38
▸ ALOX15 P16050 2/20 0.38
▸ CA1 P00915 1/20 0.38
▸ CA2 P00918 1/20 0.38
▸ CYBB P04839 1/20 0.38
▸ APP P05067 1/20 0.38
▸ SNCA P37840 1/20 0.38
▸ NOX3 Q9HBY0 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10370002 0.89 GAA (0.48) MAPTRAB9ALMNAPKMGAA
SCHEMBL433238 0.88 MAPT (0.41) MAPTRAB9AL3MBTL1CASP3SENP8
SCHEMBL436033 0.86 NOX1 (0.41) MAPTRAB9AL3MBTL1LMNAGAA
SCHEMBL434466 0.83 MAPT (0.46) MAPTRAB9AL3MBTL1LMNAGAA
SCHEMBL563959 0.81 GAA (0.42) MAPTRAB9AL3MBTL1LMNAGAA
SCHEMBL433635 0.81 MAPT (0.39) MAPTRAB9AGAAMEN1KMT2A
SCHEMBL433232 0.79 NOX1 (0.42) MAPTRAB9AL3MBTL1LMNAGAA
SCHEMBL436040 0.79 NOX1 (0.38) MAPTRAB9AL3MBTL1LMNAGAA
SCHEMBL563322 0.79 NOX1 (0.38) MAPTRAB9AL3MBTL1LMNAGAA
SCHEMBL434952 0.76 SNCA (0.48) MAPTRAB9AGAAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11851685-B2 Zwitterion buffer containing compositions and uses in electroanalytical devices and methods ROCHE DIABETES CARE, INC. (US) 2023-12-26 — — US claimed
EP-1867732-A1 Reagents, methods and devices for detecting analytes Bayer Corporation (US) 2007-12-19 — — EP claimed
EP-1293574-B1 Reagents, methods and devices for detecting analytes BAYER CORP (US) 2007-11-21 — — EP claimed
US-7163616-B2 Reagents and methods for detecting analytes, and devices comprising reagents for detecting analytes BAYER CORPORATION (US) 2007-01-16 — — US claimed
US-20030094384-A1 Reagents and methods for detecting analytes, and devices comprising reagents for detecting analytes ASCENSIA DIABETES CARE HOLDINGS AG (CH) 2003-05-22 — — US claimed
EP-1293574-A2 Reagents, methods and devices for detecting analytes Bayer Corporation (US) 2003-03-19 — — EP claimed
EP-0747984-B1 Mediators suitable for the electrochemical regeneration of NADH, NADPH or analogs thereof BAYER AG (US) 2002-08-14 — — EP claimed
EP-0747984-A2 Mediators suitable for the electrochemical regeneration of NADH, NADPH or analogs thereof Bayer Corporation (US) 1996-12-11 — — EP claimed
US-5520786-A ELECTRODE SURFACE HAS BEEN IMPARTED BY A MEDIATOR FUNCTION COMPRISING ONE OR MORE MEDIATOR COMPOUNDS SELECTED FROM SUBSTITUTED OR UNSUBSTITUTED 3-PHENYLIMINO-3H-PHENOTHIAZINES AND 3-PHENYLIMINO-3H-PHENOXAZINES BAYER CORPORATION (US) 1996-05-28 — — US claimed
US-11851685-B2 Zwitterion buffer containing compositions and uses in electroanalytical devices and methods ROCHE DIABETES CARE, INC. (US) 2023-12-26 — — US disclosed
US-20220275348-A1 ZWITTERION BUFFER CONTAINING COMPOSITIONS AND USES IN ELECTROANALYTICAL DEVICES AND METHODS ROCHE DIABETES CARE, INC. 2022-09-01 — — US disclosed
US-11180790-B2 Reagents and methods for detecting analytes ASCENSIA DIABETES CARE HOLDINGS AG (CH) 2021-11-23 — — US disclosed
EP-3388824-B1 METHODS OF DETECTING HIGH ANTIOXIDANT LEVELS DURING ELECTROCHEMICAL MEASUREMENTS AND FAILSAFING AN ANALYTE CONCENTRATION THEREFROM AS WELL AS DEVICES AND SYSTEMS INCORPORTING THE SAME ROCHE DIABETES CARE GMBH (DE) 2021-04-14 — — EP disclosed
US-20200270668-A1 REAGENTS AND METHODS FOR DETECTING ANALYTES BAYER HEALTHCARE, LLC 2020-08-27 — — US disclosed
US-7163616-B2 Reagents and methods for detecting analytes, and devices comprising reagents for detecting analytes BAYER CORPORATION (US) 2007-01-16 — — US disclosed
US-20030094384-A1 Reagents and methods for detecting analytes, and devices comprising reagents for detecting analytes ASCENSIA DIABETES CARE HOLDINGS AG (CH) 2003-05-22 — — US disclosed
EP-1293574-A2 Reagents, methods and devices for detecting analytes Bayer Corporation (US) 2003-03-19 — — EP disclosed
EP-0747984-B1 Mediators suitable for the electrochemical regeneration of NADH, NADPH or analogs thereof BAYER AG (US) 2002-08-14 — — EP disclosed
EP-0747984-A2 Mediators suitable for the electrochemical regeneration of NADH, NADPH or analogs thereof Bayer Corporation (US) 1996-12-11 — — EP disclosed
US-5520786-A ELECTRODE SURFACE HAS BEEN IMPARTED BY A MEDIATOR FUNCTION COMPRISING ONE OR MORE MEDIATOR COMPOUNDS SELECTED FROM SUBSTITUTED OR UNSUBSTITUTED 3-PHENYLIMINO-3H-PHENOTHIAZINES AND 3-PHENYLIMINO-3H-PHENOXAZINES BAYER CORPORATION (US) 1996-05-28 — — US disclosed
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