Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8658916 | 0.84 | DAO (0.40) | EPHX2CRBNDDB1CYP2C19SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8665315 | 0.83 | MAPT (0.37) | EPHX2CRBNDDB1NPC1RAB9A | |
| SCHEMBL8658341 | 0.83 | DAO (0.44) | MAPTGAAMAPK1DAOALDH1A1 | |
| SCHEMBL9850086 | 0.78 | DDB1 (0.69) | EPHX2CRBNDDB1CYP2C19GAA | |
| SCHEMBL1011633 | 0.78 | DDB1 (0.69) | EPHX2CRBNDDB1CYP2C19GAA | |
| SCHEMBL8663563 | 0.77 | ALDH1A1 (0.48) | CYP2C19NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL8667805 | 0.77 | CYP1A2 (0.53) | CYP2C19SMN1; SMN2DAOALDH1A1 | |
| SCHEMBL8661737 | 0.77 | EPHX2 (0.43) | EPHX2CRBNDDB1NPC1RAB9A | |
| SCHEMBL9850110 | 0.76 | DDB1 (0.67) | EPHX2CRBNDDB1CYP2C19GAA | |
| SCHEMBL10335076 | 0.75 | DDB1 (0.51) | EPHX2CRBNDDB1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064202-A2 | A NEW CRYSTALLINE FORM G OF (5S)-5-[4-(5-CHLORO-PYRIDIN-2-YLOXY)-PIPERIDINE-1-SULFONYL-METHYL]-5-METHYL-IMIDAZOLIDINE-2,4-DIONE (I) AND INTERMEDIATES THEREOF. | AstraZeneca AB (SE) | 2009-06-03 | — | — | EP | claimed |
| WO-2007106022-A2 | A NEW CRYSTALLINE FORM G OF (5S) -5- [4- (5-CHLORO-PYRIDIN-2- YLOXY) -PIPERIDINE-1-SULFONYLMETHYL] - 5 -METHYL -IMIDAZOLIDINE - 2,4-DIONE (I) AND INTERMEDIATES THEREOF. | ASTRAZENECA AB (SE) | 2007-09-20 | — | — | WO | claimed |
| US-7625934-B2 | Metalloproteinase inhibitors | ASTRAZENECA AB (SE) | 2009-12-01 | — | — | US | disclosed |
| US-20080171882-A1 | Metalloproteinase Inhibitors | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | US | disclosed |
| US-5767140-A | USEFUL FOR TREATING AIDS | SOUTHERN RESEARCH INSTITUTE (US) | 1998-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171882-A1 | Metalloproteinase Inhibitors | MMP9, MMP12, MMP14 | EPHX2 1178/4885CRBN 4611/4885DDB1 3347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.