Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 6/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.37 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4339512 | 0.87 | MAPK14 (0.36) | MAPTALDH1A1NPSR1 | |
| SCHEMBL4341686 | 0.85 | ALOX15 (0.43) | MAPT | |
| SCHEMBL4346788 | 0.82 | MMP2 (0.41) | GSK3BMAPTROCK2PRKACAGSK3A | |
| SCHEMBL4347024 | 0.82 | KDM4E (0.47) | MAPTALDH1A1GAANPSR1 | |
| SCHEMBL4334687 | 0.81 | CYP1A2 (0.43) | MAPTALDH1A1GAAL3MBTL1KDR | |
| SCHEMBL4343913 | 0.81 | KMT2A (0.43) | MAPTALDH1A1GAANPSR1 | |
| SCHEMBL4351602 | 0.79 | GAA (0.44) | MAPTALDH1A1GAAL3MBTL1NPSR1 | |
| SCHEMBL4344250 | 0.76 | KIF11 (0.47) | KIF11GSK3BMAPTIDO1TDO2 | |
| SCHEMBL8050551 | 0.75 | KIF11 (0.43) | KIF11GSK3BMAPTIDO1TDO2 | |
| SCHEMBL4337592 | 0.73 | DHODH (0.50) | MAPTALDH1A1KDRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501797-B1 | 3-(SUBSTITUTED AMINO)-1H-INDOLE-2-CARBOXYLIC ACID ESTER AND 3-(SUBSTITUTED AMINO)-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ESTER DERIVATIVES AS INTERLEUKIN-4 GENE EXPRESSION INHIBITORS | AVENTIS PHARMA INC (US) | 2009-08-05 | — | — | EP | claimed |