Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9440912 | 0.87 | TSHR (0.49) | ALDH1A1HPGDKDM4ESMN1; SMN2LMNA | |
| SCHEMBL23135332 | 0.86 | SMN1; SMN2 (0.58) | PARP1ALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL9440996 | 0.79 | RXRA (0.42) | ALDH1A1HPGDKDM4ESMN1; SMN2LMNA | |
| SCHEMBL23135333 | 0.78 | DAGLA (0.43) | ALDH1A1KDM4ESMN1; SMN2GAADAGLA | |
| SCHEMBL4333153 | 0.78 | TSHR (0.46) | ALDH1A1HPGDKDM4ESMN1; SMN2CYP4F2 | |
| SCHEMBL9440823 | 0.78 | MEN1 (0.59) | ALDH1A1HPGDKDM4ESMN1; SMN2MAPT | |
| SCHEMBL4343281 | 0.78 | FAAH (0.53) | ALDH1A1HPGDKDM4ESMN1; SMN2CYP4F2 | |
| SCHEMBL4329577 | 0.77 | ENPP3 (0.46) | ALDH1A1HPGDKDM4EPTPN1MAPT | |
| SCHEMBL6260123 | 0.77 | NPPA (0.45) | ALDH1A1HPGDKDM4ESMN1; SMN2LMNA | |
| SCHEMBL3048357 | 0.77 | DAGLA (0.54) | HPGDMAPTDAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5371098-A | Use of oxazole compounds to treat osteoporosis | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-12-06 | — | — | US | disclosed |
| US-5239080-A | Oxazole compounds and their use as antidiabetic and bone-reduction inhibitory agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-08-24 | — | — | US | disclosed |
| EP-0440183-A1 | Oxazole compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-08-07 | — | — | EP | disclosed |