Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.52 |
| ▸ | ACR | P10323 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 5/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4330723 | 0.84 | PRSS1 (0.61) | MAPTTDP1L3MBTL1PRSS1ACR | |
| SCHEMBL4326106 | 0.84 | NPC1 (0.63) | MAPTALDH1A1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL4330728 | 0.82 | ADORA3 (0.48) | MAPTALDH1A1KDM4ETDP1L3MBTL1 | |
| SCHEMBL474535 | 0.81 | ALDH1A1 (0.59) | MAPTALDH1A1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL14062417 | 0.80 | MAPT (0.75) | MAPTALDH1A1TDP1L3MBTL1PRSS1 | |
| SCHEMBL14062466 | 0.80 | MAPT (0.75) | MAPTALDH1A1TDP1L3MBTL1PRSS1 | |
| SCHEMBL4322692 | 0.80 | ALDH1A1 (0.52) | MAPTALDH1A1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL4330172 | 0.79 | MAPT (0.55) | MAPTALDH1A1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL4328007 | 0.79 | ALDH1A1 (0.59) | MAPTALDH1A1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL14062435 | 0.78 | MAPT (0.83) | MAPTALDH1A1TDP1L3MBTL1PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009146013-A1 | MYOSIN LIGHT CHAIN PHOSPHATASE INHIBITORS | GEORGETOWN UNIVERSITY (US) | 2009-12-03 | — | — | WO | claimed |
| WO-2009146013-A1 | MYOSIN LIGHT CHAIN PHOSPHATASE INHIBITORS | GEORGETOWN UNIVERSITY (US) | 2009-12-03 | — | — | WO | disclosed |