Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | ALPG | P10696 | 1/20 | 0.31 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.31 |
| ▸ | ARG1 | P05089 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4333586 | 0.85 | SMN1; SMN2 (0.33) | HTTTLR8SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4314338 | 0.82 | SMN1; SMN2 (0.39) | TLR8SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL27845254 | 0.79 | TLR8 (0.42) | TLR8SMN1; SMN2ALDH1A1POLBKMT2A | |
| SCHEMBL3810263 | 0.75 | ALDH1A1 (0.35) | SMN1; SMN2NPC1RAB9AALDH1A1ARG1 | |
| SCHEMBL7481370 | 0.73 | KMT2A (0.53) | HPGDALDH1A1POLBKMT2AALPG | |
| SCHEMBL31210326 | 0.72 | ARG1 (0.39) | TLR8SMN1; SMN2RAB9AALDH1A1PIM3 | |
| SCHEMBL7362579 | 0.71 | ALDH1A1 (0.33) | SMN1; SMN2NPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL18839651 | 0.70 | KDM4E (0.44) | SMN1; SMN2NPC1ALDH1A1POLBKMT2A | |
| SCHEMBL7557979 | 0.69 | TLR8 (0.37) | TLR8HPGDALDH1A1POLBKMT2A | |
| SCHEMBL28205879 | 0.69 | CYP11B1 (0.42) | HTTHPGDSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009141386-A1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-11-26 | — | — | WO | disclosed |