Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 4/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | HTR2C | P28335 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | PTAFR | P25105 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4332243 | 0.85 | PTAFR (0.45) | DRD3DRD2HTR2CHTR1AHTR2A | |
| SCHEMBL4333849 | 0.85 | DRD2 (0.46) | DRD3DRD2NAMPTDRD4 | |
| SCHEMBL4320012 | 0.85 | LMNA (0.46) | DRD3DRD2DRD4NPC1LMNA | |
| SCHEMBL4326354 | 0.83 | NAMPT (0.46) | DRD3DRD2HTR2CHTR1AHTR2A | |
| SCHEMBL4336046 | 0.83 | LMNA (0.46) | DRD3DRD2NPC1LMNAPOLB | |
| SCHEMBL4324148 | 0.83 | SCN9A (0.46) | NAMPT | |
| SCHEMBL4331873 | 0.83 | NPC1 (0.50) | DRD3DRD2NAMPTDRD4NPC1 | |
| SCHEMBL4330789 | 0.83 | NPC1 (0.49) | DRD3DRD2DRD4NPC1LMNA | |
| SCHEMBL4325414 | 0.83 | KMT2A (0.47) | DRD3DRD2HTR1ANAMPTDRD1 | |
| SCHEMBL4327361 | 0.81 | S1PR1 (0.40) | NAMPTPTAFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009147121-A1 | CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-10 | — | — | WO | claimed |
| WO-2009147121-A1 | CARBOXYL SUBSTITUTED INDOLES FOR USE AS PPAR ALPHA MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-10 | — | — | WO | disclosed |