Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4318856 | 0.86 | TSHR (0.47) | TSHRHSD17B10LMNAL3MBTL1GLA | |
| SCHEMBL17977307 | 0.85 | MKNK1 (0.44) | TSHRHSD17B10LMNAL3MBTL1GLA | |
| SCHEMBL5178794 | 0.83 | TSHR (0.49) | TSHRHSD17B10LMNAKDM4EKMT2A | |
| SCHEMBL1205875 | 0.83 | TDP1 (0.51) | TSHRHSD17B10LMNAL3MBTL1GLA | |
| SCHEMBL182820 | 0.80 | ALDH1A1 (0.49) | TSHRHSD17B10KDM4EKMT2AHTT | |
| SCHEMBL5460045 | 0.77 | L3MBTL1 (0.65) | TSHRL3MBTL1GLAKDM4EKMT2A | |
| Water SCHEMBL9316910 | 0.77 | ALDH1A1 (0.62) | TSHRHSD17B10LMNAL3MBTL1GLA | |
| SCHEMBL7143352 | 0.76 | HCRTR1 (0.35) | TSHRHSD17B10L3MBTL1GLAKDM4E | |
| SCHEMBL4333771 | 0.76 | ALDH1A1 (0.46) | TSHRHSD17B10KDM4EKMT2AHTT | |
| SCHEMBL127280 | 0.75 | ALDH1A1 (0.39) | TSHRHSD17B10L3MBTL1GLAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2042502-A1 | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2009-04-01 | — | — | EP | disclosed |
| EP-1544199-B1 | NITROGENOUS CONDENSED-RING COMPOUND AND USE THEREOF AS HIV INTEGRASE INHIBITOR | JAPAN TOBACCO INC (JP) | 2008-10-15 | — | — | EP | disclosed |
| US-20080161311-A1 | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. | 2008-07-03 | — | — | US | disclosed |
| EP-1511719-B1 | AMIDE DERIVATIVES AS INHIBITORS OF THE ENZYMATIC ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2007-09-19 | — | — | EP | disclosed |
| US-7211572-B2 | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2007-05-01 | — | — | US | disclosed |
| US-7115777-B2 | Amide derivatives as inhibitors of the enzymatic activity of renin | NOVARTIS AG (CH) | 2006-10-03 | — | — | US | disclosed |
| US-20060052361-A1 | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. | 2006-03-09 | — | — | US | disclosed |
| US-20050234126-A1 | Amide derivatives as inhibitors of the enzymatic activity of renin | NOVARTIS AG (CH) | 2005-10-20 | — | — | US | disclosed |
| EP-1544199-A1 | NITROGENOUS CONDENSED-RING COMPOUND AND USE THEREOF AS HIV INTEGRASE INHIBITOR | JAPAN TOBACCO INC. (JP) | 2005-06-22 | — | — | EP | disclosed |
| US-20050054645-A1 | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2005-03-10 | — | — | US | disclosed |
| EP-1511719-A1 | AMIDE DERIVATIVES AS INHIBITORS OF THE ENZYMATIC ACTIVITY OF RENIN | Novartis AG (CH) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003099767-A1 | AMIDE DERIVATIVES AS INHIBITORS OF THE ENZYMATIC ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2003-12-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054645-A1 | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor | NNMT, PNP, DNTT | TSHR 4778/4885HSD17B10 1048/4885LMNA 3234/4885 |
| US-20050234126-A1 | Amide derivatives as inhibitors of the enzymatic activity of renin | REN, ACE, AGT | TSHR 2440/4885HSD17B10 395/4885LMNA 3662/4885 |
| US-20060052361-A1 | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor | NNMT, PNP, DNTT | TSHR 4778/4885HSD17B10 1048/4885LMNA 3234/4885 |
| US-20080161311-A1 | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor | DNTT, PNP, NNMT | TSHR 4748/4885HSD17B10 935/4885LMNA 2372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.