Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.43 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.42 |
| ▸ | PTGIR | P43119 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL434387 | 0.92 | HRH3 (0.43) | HRH3OPRM1PTGIRKMT2AMEN1 | |
| SCHEMBL434778 | 0.75 | PTGIR (0.44) | HRH3PTGIRKMT2AMEN1MAPK1 | |
| SCHEMBL432941 | 0.70 | OPRK1 (0.44) | OPRM1OPRK1OPRD1KMT2AMEN1 | |
| SCHEMBL10083363 | 0.70 | OPRK1 (0.44) | OPRM1OPRK1OPRD1KMT2AMEN1 | |
| SCHEMBL10083357 | 0.70 | AKR1C1 (0.50) | OPRM1OPRK1OPRD1 | |
| SCHEMBL11456541 | 0.69 | DRD2 (0.48) | OPRM1OPRK1OPRD1ARRB1SIGMAR1 | |
| SCHEMBL10798764 | 0.68 | OPRM1 (0.45) | HRH3OPRM1PTGIRKMT2ASIGMAR1 | |
| SCHEMBL13386512 | 0.68 | PARP1 (0.48) | OPRM1OPRK1OPRD1 | |
| SCHEMBL8437918 | 0.68 | OPRM1 (0.51) | HRH3OPRM1PTGIRKMT2ASIGMAR1 | |
| SCHEMBL4931908 | 0.68 | HRH3 (0.53) | HRH3OPRM1PTGIRKMT2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012012410-A2 | KAPPA OPIOID RECEPTOR AGONISTS | DR. REDDY'S LABORATORIES LTD. (IN) | 2012-01-26 | — | — | WO | disclosed |