SCHEMBL433539

SCHEMBL433539

Clc1ccc([C]2CC2)c(Cl)c1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 1/20 0.52
TP53 P04637 1/20 0.48
HSD11B1 P28845 2/20 0.45
MAPT P10636 2/20 0.43
HPGD P15428 1/20 0.43
LMNA P02545 1/20 0.43
TSHR P16473 3/20 0.42
CYP3A4 P08684 2/20 0.42
HSD17B10 Q99714 1/20 0.42
ALDH1A1 P00352 2/20 0.41
HSP90AA1 P07900 2/20 0.41
HSP90AB1 P08238 2/20 0.41
KDM4E B2RXH2 1/20 0.41
MGAM O43451 1/20 0.41
GAA P10253 1/20 0.41
SI P14410 1/20 0.41
RAB9A P51151 1/20 0.41
MGAM2 Q2M2H8 1/20 0.41
S100A4 P26447 1/20 0.41
PTGS2 P35354 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL432355 0.91 MAPT (0.49) AHRTP53HSD11B1MAPTHPGD
SCHEMBL432638 0.91 AHR (0.48) AHRTP53HSD11B1MAPTHPGD
SCHEMBL434607 0.89 AHR (0.47) AHRTP53HSD11B1MAPTHPGD
SCHEMBL6075519 0.82 AHR (0.41) AHRTP53HSD11B1MAPTHPGD
SCHEMBL464507 0.81 AHR (0.64) AHRTP53HSD11B1MAPTTSHR
SCHEMBL29624840 0.81 AHR (0.64) AHRTP53HSD11B1MAPTTSHR
SCHEMBL15567120 0.80 TP53 (0.48) TP53MAPTTSHRCYP3A4HSD17B10
SCHEMBL17514566 0.76 NISCH (0.49) TP53HSD11B1HPGDKDM4EGAA
SCHEMBL433272 0.76 KMO (0.40) HSD11B1S100A4HTTSRD5A2
SCHEMBL4452962 0.74 AHR (0.56) AHRTP53HSD11B1MAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200331904-A1 3-AMINO-[1,2,4]-TRIAZOLE DERIVATIVES AND THEIR USE FOR CONTROLLING UNDESIRED PLANT GROWTH BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2020-10-22 US claimed
EP-3720853-A1 3-AMINO-[1,2,4]-TRIAZOLE DERIVATIVES AND THEIR USE FOR CONTROLLING UNDESIRED PLANT GROWTH Bayer CropScience Aktiengesellschaft (DE) 2020-10-14 EP claimed
CN-111448194-A 3-amino- [1,2, 4] -triazole derivatives and their use for controlling undesired vegetation 拜耳作物科学股份公司 2020-07-24 CN claimed
WO-2019110398-A1 3-AMINO-[1,2,4]-TRIAZOLE DERIVATIVES AND THEIR USE FOR CONTROLLING UNDESIRED PLANT GROWTH BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2019-06-13 WO claimed
US-20110166132-A1 Gamma Secretase Modulators AMGEN INC. (US) 2011-07-07 US claimed
US-5051447-A Applying aromatic oximes to plants, seeds or soils BASF AKTIENGESELLSCHAFT (DE) 1991-09-24 US claimed
EP-0354571-A1 Oximethers, method for their preparation and fungicides containing them BASF Aktiengesellschaft (DE) 1990-02-14 EP claimed
WO-2024132895-A1 MICROBIOCIDAL DIHYDROOXADIAZINYL PYRIDAZINONE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2024-06-27 WO disclosed
WO-2024132901-A1 MICROBIOCIDAL PYRIDAZINE DIHYDROOXADIAZINE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2024-06-27 WO disclosed
US-20200331904-A1 3-AMINO-[1,2,4]-TRIAZOLE DERIVATIVES AND THEIR USE FOR CONTROLLING UNDESIRED PLANT GROWTH BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2020-10-22 US disclosed
EP-3720853-A1 3-AMINO-[1,2,4]-TRIAZOLE DERIVATIVES AND THEIR USE FOR CONTROLLING UNDESIRED PLANT GROWTH Bayer CropScience Aktiengesellschaft (DE) 2020-10-14 EP disclosed
CN-111448194-A 3-amino- [1,2, 4] -triazole derivatives and their use for controlling undesired vegetation 拜耳作物科学股份公司 2020-07-24 CN disclosed
WO-2019110398-A1 3-AMINO-[1,2,4]-TRIAZOLE DERIVATIVES AND THEIR USE FOR CONTROLLING UNDESIRED PLANT GROWTH BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2019-06-13 WO disclosed
US-20100167935-A1 Pyrimidine derivatives and their use for controlling undesired plant growth BAYER CROPSCIENCE AG (DE) 2010-07-01 US disclosed
US-5051447-A Applying aromatic oximes to plants, seeds or soils BASF AKTIENGESELLSCHAFT (DE) 1991-09-24 US disclosed
US-4997973-A Ortho-substituted benzyl carboxylates and fungicides containing these compounds BASF AKTIENGESELLSCHAFT (DE) 1991-03-05 US disclosed
US-4952720-A Ortho-substituted benzyl carboxylates and fungicides which contain these compounds BASF AKTIENGSELLSCHAFT (DE) 1990-08-28 US disclosed
EP-0337211-B1 ORTHO-SUBSTITUTED CARBOXYLIC-ACID BENZYL ESTERS AND FUNGICIDES CONTAINING THEM BASF Aktiengesellschaft (DE) 1990-07-11 EP disclosed
EP-0354571-A1 Oximethers, method for their preparation and fungicides containing them BASF Aktiengesellschaft (DE) 1990-02-14 EP disclosed
EP-0337211-A1 Ortho-substituted carboxylic-acid benzyl esters and fungicides containing them BASF Aktiengesellschaft (DE) 1989-10-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100167935-A1 Pyrimidine derivatives and their use for controlling undesired plant growth TYMS, TYMP, UMPS AHR 3435/4885TP53 1729/4885HSD11B1 3092/4885
US-20200331904-A1 3-AMINO-[1,2,4]-TRIAZOLE DERIVATIVES AND THEIR USE FOR CONTROLLING UNDESIRED PLANT GROWTH NAT1, AGXT, CYP4Z1 AHR 1025/4885TP53 3505/4885HSD11B1 481/4885
US-20110166132-A1 Gamma Secretase Modulators BACE1, BACE2, PSEN1 AHR 4278/4885TP53 2551/4885HSD11B1 1270/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.