Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 2/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | FASN | P49327 | 1/20 | 0.32 |
| ▸ | S100A4 | P26447 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 2/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17514805 | 0.88 | GRM2 (0.35) | PTGS2KMOEGLN2GRM2HSD11B1 | |
| SCHEMBL434637 | 0.88 | AHR (0.39) | HSD11B1MAPK14KDM4ENPC1TP53 | |
| SCHEMBL432660 | 0.86 | ALDH1A1 (0.34) | PTGS2KMOGRM2MAPK14KDM4E | |
| SCHEMBL433574 | 0.86 | KMO (0.35) | PTGS2KMOEGLN2GRM2HSD11B1 | |
| SCHEMBL17514628 | 0.83 | PTGS2 (0.34) | PTGS2KMOEGLN2GRM2HSD11B1 | |
| SCHEMBL17514857 | 0.83 | PTGS2 (0.37) | PTGS2KMOEGLN2GRM2HSD11B1 | |
| SCHEMBL1274798 | 0.82 | HSD11B1 (0.42) | PTGS2KMOEGLN2GRM2HSD11B1 | |
| SCHEMBL17514578 | 0.79 | KMO (0.40) | PTGS2KMOEGLN2GRM2HSD11B1 | |
| SCHEMBL432908 | 0.78 | PTGS1 (0.34) | HSD11B1KDM4ENPC1RAB9APDK2 | |
| SCHEMBL17514653 | 0.77 | NISCH (0.37) | GRM2HSD11B1FASNMAPK14KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7151097-B2 | Bicyclic pyrazolyl and imidazolyl compounds and uses thereof | PFIZER INC. (US) | 2006-12-19 | — | — | US | claimed |
| WO-2016026830-A1 | NOVEL FUNGICIDAL PYRAZOLE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-02-25 | — | — | WO | disclosed |
| EP-2595985-A1 | ISOXAZOLE, ISOTHIAZOLE, FURANE AND THIOPHENE COMPOUNDS AS MICROBICIDES | Syngenta Participations AG (CH) | 2013-05-29 | — | — | EP | disclosed |
| EP-2595984-A1 | MICROBICIDES | Syngenta Participations AG (CH) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012010568-A1 | MICROBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-01-26 | — | — | WO | disclosed |
| WO-2012010567-A1 | ISOXAZOLE, ISOTHIAZOLE, FURANE AND THIOPHENE COMPOUNDS AS MICROBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-01-26 | — | — | WO | disclosed |
| EP-0121979-B1 | AZOLYLMETHYL TETRAHYDROFURAN DERIVATIVES AS PLANT GROWTH REGULATORS AND FUNGICIDES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-09-26 | — | — | EP | disclosed |