Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 3/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TTR | P02766 | 1/20 | 0.30 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28418518 | 0.83 | POLB (0.33) | ALDH1A1HPGDHSD17B10KDM4ECYP2D6 | |
| SCHEMBL29007685 | 0.81 | HDAC4 (0.32) | ALDH1A1HPGDTHRBTDP1RAB9A | |
| SCHEMBL6846865 | 0.81 | NPC1 (0.35) | ALDH1A1HPGDHSD17B10KDM4EMEN1 | |
| SCHEMBL6851099 | 0.77 | PTPN1 (0.31) | ALDH1A1HPGDHSD17B10BCL2L1 | |
| SCHEMBL6850680 | 0.75 | PTPN5 (0.31) | ALDH1A1HPGDHSD17B10BCL2L1 | |
| SCHEMBL6852957 | 0.75 | ALDH1A1 (0.31) | ALDH1A1HPGDHSD17B10BCL2L1 | |
| SCHEMBL19379856 | 0.72 | GRM4 (0.33) | — | |
| SCHEMBL10872336 | 0.71 | SRR (0.33) | ALDH1A1HSD17B10TDP1KDM4ERAB9A | |
| SCHEMBL7551777 | 0.71 | ALDH1A1 (0.33) | ALDH1A1HPGDHSD17B10THRBTDP1 | |
| SCHEMBL6852914 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115322110-B | Method for synthesizing eltrombopag intermediate 3 '-amino-2' -hydroxybiphenyl-3-carboxylic acid | 常熟理工学院 | 2024-03-19 | — | — | CN | claimed |
| CN-115322110-A | Method for synthesizing eltrombopag intermediate 3 '-amino-2' -hydroxybiphenyl-3-carboxylic acid | 常熟理工学院 | 2022-11-11 | — | — | CN | claimed |
| CN-114317127-A | Fluoride-free cleaning agent, and preparation method and application thereof | 嘉庚创新实验室 | 2022-04-12 | — | — | CN | claimed |
| CN-114230517-A | Method for processing eltrombopag | 杭州煌森生物科技有限公司 | 2022-03-25 | — | — | CN | claimed |
| CN-115322110-B | Method for synthesizing eltrombopag intermediate 3 '-amino-2' -hydroxybiphenyl-3-carboxylic acid | 常熟理工学院 | 2024-03-19 | — | — | CN | disclosed |
| CN-115322110-B | Method for synthesizing eltrombopag intermediate 3 '-amino-2' -hydroxybiphenyl-3-carboxylic acid | 常熟理工学院 | 2024-03-19 | — | — | CN | disclosed |
| CN-115322110-B | Method for synthesizing eltrombopag intermediate 3 '-amino-2' -hydroxybiphenyl-3-carboxylic acid | 常熟理工学院 | 2024-03-19 | — | — | CN | disclosed |
| CN-115322110-A | Method for synthesizing eltrombopag intermediate 3 '-amino-2' -hydroxybiphenyl-3-carboxylic acid | 常熟理工学院 | 2022-11-11 | — | — | CN | disclosed |
| CN-115322110-A | Method for synthesizing eltrombopag intermediate 3 '-amino-2' -hydroxybiphenyl-3-carboxylic acid | 常熟理工学院 | 2022-11-11 | — | — | CN | disclosed |
| CN-115322110-A | Method for synthesizing eltrombopag intermediate 3 '-amino-2' -hydroxybiphenyl-3-carboxylic acid | 常熟理工学院 | 2022-11-11 | — | — | CN | disclosed |
| CN-114317127-A | Fluoride-free cleaning agent, and preparation method and application thereof | 嘉庚创新实验室 | 2022-04-12 | — | — | CN | disclosed |
| CN-114230517-A | Method for processing eltrombopag | 杭州煌森生物科技有限公司 | 2022-03-25 | — | — | CN | disclosed |
| EP-1889838-B1 | Thrombopoietin mimetics | SMITHKLINE BEECHAM CORP (US) | 2009-10-14 | — | — | EP | disclosed |
| EP-1889838-A1 | Thrombopoietin mimetics | SmithKline Beecham Corporation (US) | 2008-02-20 | — | — | EP | disclosed |
| EP-1864981-A1 | Thrombopoietin mimetics | SmithKline Beecham Corporation (US) | 2007-12-12 | — | — | EP | disclosed |
| US-20070129338-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION | 2007-06-07 | — | — | US | disclosed |
| US-20040019190-A1 | Thrombopoietin mimetics | NOVARTIS AG (CH) | 2004-01-29 | — | — | US | disclosed |
| EP-1294378-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2004-01-28 | — | — | EP | disclosed |
| EP-1294378-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001089457-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129338-A1 | THROMBOPOIETIN MIMETICS | MPL, THPO, TEK | ALDH1A1 1012/4885HPGD 1200/4885HSD17B10 2374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.