⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6852957 | 0.79 | ALDH1A1 (0.31) | — | |
| SCHEMBL4336208 | 0.70 | ALDH1A1 (0.34) | — | |
| SCHEMBL28418518 | 0.66 | POLB (0.33) | — | |
| SCHEMBL6851099 | 0.64 | PTPN1 (0.31) | — | |
| SCHEMBL6849472 | 0.63 | L3MBTL1 (0.36) | — | |
| SCHEMBL7551777 | 0.62 | ALDH1A1 (0.33) | — | |
| SCHEMBL6851030 | 0.61 | CA2 (0.33) | — | |
| SCHEMBL28106479 | 0.61 | KDM4E (0.33) | — | |
| SCHEMBL9319435 | 0.59 | SIGMAR1 (0.36) | — | |
| SCHEMBL12615366 | 0.59 | CXCR5 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294378-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2004-01-28 | — | — | EP | disclosed |
| EP-1294378-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001089457-A2 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-11-29 | — | — | WO | disclosed |