Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TPMT | P51580 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CTSV | O60911 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16784742 | 0.83 | MEN1 (0.56) | KDM4EPOLBUSP2HSD17B10MAPT | |
| SCHEMBL25039858 | 0.82 | KDM4E (0.54) | KDM4EPOLBUSP2HSD17B10PKM | |
| SCHEMBL13064989 | 0.80 | TPMT (0.54) | KDM4EPOLBUSP2HSD17B10PKM | |
| SCHEMBL8622541 | 0.79 | TUBB4A (0.57) | KDM4EPOLBUSP2HSD17B10RXFP1 | |
| SCHEMBL27972004 | 0.77 | CTSV (0.58) | KDM4EPOLBUSP2HSD17B10PKM | |
| SCHEMBL1438926 | 0.77 | PKM (0.62) | KDM4EPOLBUSP2HSD17B10PKM | |
| SCHEMBL4299733 | 0.75 | PKM (0.60) | KDM4EPOLBUSP2HSD17B10PKM | |
| SCHEMBL8541790 | 0.75 | KDM4E (0.65) | KDM4EHSD17B10LCKFYNCYP1A2 | |
| SCHEMBL11593017 | 0.75 | MEN1 (0.58) | KDM4EHSD17B10LCKFYNMAPT | |
| SCHEMBL8911580 | 0.74 | PKM (0.58) | KDM4EPOLBUSP2HSD17B10PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343988-B2 | Inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA, N.V (BE) | 2013-01-01 | — | — | US | disclosed |
| US-8268833-B2 | Inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA, N.V. (BE) | 2012-09-18 | — | — | US | disclosed |
| US-20090170881-A1 | NEW INHIBITORS OF HISTONE DEACETYLASE | ANGIBAUD PATRICK RENE | 2009-07-02 | — | — | US | disclosed |
| US-20090170836-A1 | NEW INHIBITORS OF HISTONE DEACETYLASE | ANGIBAUD PATRICK RENE | 2009-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170836-A1 | NEW INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC11 | KDM4E 89/4885POLB 598/4885USP2 1289/4885 |
| US-20090170881-A1 | NEW INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC11 | KDM4E 89/4885POLB 598/4885USP2 1289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.