Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.47 |
| ▸ | PTGFR | P43088 | 1/20 | 0.47 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.47 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3867561 | 0.95 | HPGD (0.53) | ALDH1A1HPGDPTGER1PTGFRPTGER3 | |
| SCHEMBL6278596 | 0.93 | HPGD (0.55) | ALDH1A1HPGDPTGER1PTGFRPTGER3 | |
| SCHEMBL5717731 | 0.89 | HPGD (0.47) | ALDH1A1HPGDPTGER1PTGFRPTGER3 | |
| SCHEMBL6282567 | 0.79 | PTGER1 (0.45) | ALDH1A1HPGDPTGER1PTGFRPTGER3 | |
| SCHEMBL6369341 | 0.78 | FBP1 (0.46) | ALDH1A1HPGDPTGER1PTGFRPTGER3 | |
| SCHEMBL2213224 | 0.78 | HPGD (0.56) | ALDH1A1HPGDNPC1RAB9AMAPT | |
| SCHEMBL5717752 | 0.77 | NPC1 (0.43) | ALDH1A1HPGDPTGER1PTGFRPTGER3 | |
| SCHEMBL8524729 | 0.75 | RAB9A (0.49) | ALDH1A1HPGDNPC1RAB9AMAPT | |
| SCHEMBL6277977 | 0.75 | CA2 (0.44) | ALDH1A1HPGDPTGER1PTGFRPTGER3 | |
| SCHEMBL6285444 | 0.75 | CA2 (0.44) | ALDH1A1HPGDPTGER1PTGFRPTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009144263-A2 | PROCESS FOR OBTAINING 4-HYDROXY-6-METHYL-5, 6-DIHYDRO-4H-THIENO [2,3-b] THIOPYRAN-7, 7-DIOXIDE AND ITS ENANTIOMERS, AND APPLICATIONS THEREOF | RAGACTIVES, S.L.U. (ES) | 2009-12-03 | — | — | WO | claimed |
| CN-103980289-B | Thieno-thiopyrano pyrazole compound and pharmaceutical applications thereof | 沈阳药科大学 | 2017-04-26 | — | — | CN | disclosed |
| CN-103626787-B | Thienothio compound and application thereof | 沈阳药科大学 | 2016-06-15 | — | — | CN | disclosed |
| CN-103980289-A | Thieno-thiopyrano pyrazole compound and pharmaceutical applications thereof | UNIV SHENYANG PHARMACEUTICAL | 2014-08-13 | — | — | CN | disclosed |
| CN-103626787-A | Thienothio compound and application thereof | UNIV SHENYANG PHARMACEUTICAL | 2014-03-12 | — | — | CN | disclosed |
| WO-2009144263-A2 | PROCESS FOR OBTAINING 4-HYDROXY-6-METHYL-5, 6-DIHYDRO-4H-THIENO [2,3-b] THIOPYRAN-7, 7-DIOXIDE AND ITS ENANTIOMERS, AND APPLICATIONS THEREOF | RAGACTIVES, S.L.U. (ES) | 2009-12-03 | — | — | WO | disclosed |
| EP-1918293-A1 | Process for the preparation of 6-substituted-4-oxo-thieno [2,3b]thiopyran-2-sulfonic acid | Sandoz AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| US-5756768-A | BY-PRODUCT INHIBITION | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1998-05-26 | — | — | US | disclosed |
| EP-0189690-B1 | SUBSTITUTED AROMATIC SULFONAMIDES, THEIR PREPARATION AND OPHTHALMIC COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1989-03-01 | — | — | EP | disclosed |
| US-4677115-A | Antiglaucoma thieno-thiopyran and thieno-thiepin sulfonamide derivatives, compositions, and method of use thereof | MERCK & CO., INC. (US) | 1987-06-30 | — | — | US | disclosed |
| EP-0189690-A1 | Substituted aromatic sulfonamides, their preparation and ophthalmic compositions containing them | MERCK & CO. INC. (US) | 1986-08-06 | — | — | EP | disclosed |