SCHEMBL4340146

SCHEMBL4340146

CCC(CC(C(=O)NO)c1ncco1)c1ccc(OC)cc1

nearest known ligand 0.43

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 1/20 0.43
CTSA P10619 4/20 0.40
ADAM17 P78536 5/20 0.39
MMP13 P45452 2/20 0.38
FAAH O00519 1/20 0.37
ANPEP P15144 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
KCNQ2 O43526 1/20 0.36
MMP9 P14780 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4327338 0.88 FFAR1 (0.48) FFAR1CTSAFAAH
SCHEMBL4322294 0.87 FFAR2 (0.44) CTSAHDAC8HDAC6KCNQ2
SCHEMBL4341821 0.87 HDAC8 (0.40) CTSAHDAC8HDAC6MMP9
SCHEMBL4329580 0.86 FFAR1 (0.44) FFAR1CTSAFAAH
SCHEMBL4329478 0.84 CTSA (0.39) CTSAADAM17MMP13ANPEP
SCHEMBL4328624 0.74 HDAC3 (0.39) CTSAHDAC8HDAC6
SCHEMBL4329821 0.74 FFAR2 (0.41) CTSA
SCHEMBL4331353 0.74 CTSA (0.41) CTSA
SCHEMBL4333159 0.73 FFAR2 (0.39) FFAR1CTSA
SCHEMBL4343287 0.73 CTSA (0.41) CTSA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070208065-A1 Hydroxamic Acid Derivative and Medicine Containing the Same as Active Ingredient SHIZUOKA COFFEIN CO., LTD. (JP) 2007-09-06 US claimed
EP-1787986-A1 HYDROXAMIC ACID DERIVATIVE AND MEDICINE CONTAINING THE SAME AS ACTIVE INGREDIENT SHIZUOKA COFFEIN CO., LTD. (JP) 2007-05-23 EP claimed
US-7521563-B2 Hydroxamic acid derivative and medicine containing the same as active ingredient SHIZUOKA COFFEIN CO., LTD. (JP) 2009-04-21 US disclosed
US-20070208065-A1 Hydroxamic Acid Derivative and Medicine Containing the Same as Active Ingredient SHIZUOKA COFFEIN CO., LTD. (JP) 2007-09-06 US disclosed
EP-1787986-A1 HYDROXAMIC ACID DERIVATIVE AND MEDICINE CONTAINING THE SAME AS ACTIVE INGREDIENT SHIZUOKA COFFEIN CO., LTD. (JP) 2007-05-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070208065-A1 Hydroxamic Acid Derivative and Medicine Containing the Same as Active Ingredient IL6, IL1A, TNF FFAR1 1103/4885CTSA 1028/4885ADAM17 666/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.