Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3229309 | 0.73 | — | — | |
| SCHEMBL4732409 | 0.69 | CETP (0.56) | — | |
| SCHEMBL1182281 | 0.69 | CETP (0.56) | — | |
| SCHEMBL25343042 | 0.68 | KCNN4 (0.39) | GABRA5HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL30087636 | 0.67 | KCNN4 (0.41) | GABRA5 | |
| SCHEMBL31294557 | 0.66 | DGAT1 (0.40) | GABRA5CYP2C19DGAT1CNR1CNR2 | |
| SCHEMBL4340774 | 0.66 | APLNR (0.40) | HDAC6 | |
| SCHEMBL15839715 | 0.65 | HDAC3 (0.39) | BACE1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL15821573 | 0.65 | HDAC3 (0.39) | BACE1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL15482879 | 0.64 | SMN1; SMN2 (0.33) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095712-A2 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2009-08-06 | — | — | WO | disclosed |