Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | ACLY | P53396 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8578251 | 0.75 | SIGMAR1 (0.52) | SIGMAR1HTR1AACLYDRD2DRD1 | |
| SCHEMBL13572973 | 0.75 | SIGMAR1 (0.52) | SIGMAR1HTR1AACLYOPRM1OPRL1 | |
| SCHEMBL20864244 | 0.75 | SIGMAR1 (0.56) | SIGMAR1HTR1AACLYDRD2DRD1 | |
| SCHEMBL716596 | 0.75 | SIGMAR1 (0.52) | SIGMAR1HTR1AACLYOPRM1OPRL1 | |
| SCHEMBL13572976 | 0.75 | SIGMAR1 (0.52) | SIGMAR1HTR1AACLYOPRM1OPRL1 | |
| SCHEMBL2247241 | 0.75 | SIGMAR1 (0.52) | SIGMAR1HTR1AACLYDRD2DRD1 | |
| SCHEMBL8354157 | 0.75 | SIGMAR1 (0.52) | SIGMAR1HTR1AACLYOPRM1OPRL1 | |
| SCHEMBL19658437 | 0.75 | MTNR1A (0.65) | ACLYHDAC1MALT1TP53MTNR1A | |
| SCHEMBL434889 | 0.74 | CA2 (0.44) | HTR1ALMNACA2 | |
| SCHEMBL461002 | 0.73 | TP53 (0.45) | SIGMAR1HTR1ALMNAMALT1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3181550-B1 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | BAYER IP GMBH (DE) | 2019-11-20 | — | — | EP | claimed |
| US-10093611-B2 | Benzocycloalkenes as antifungal agents | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2018-10-09 | — | — | US | claimed |
| EP-3181550-A1 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | Bayer Intellectual Property GmbH (DE) | 2017-06-21 | — | — | EP | claimed |
| US-20160023987-A1 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-01-28 | — | — | US | claimed |
| EP-2595961-A2 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | Bayer Intellectual Property GmbH (DE) | 2013-05-29 | — | — | EP | claimed |
| US-20130123322-A1 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-05-16 | — | — | US | claimed |
| WO-2012010579-A2 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | BAYER CROPSCIENCE AG (DE) | 2012-01-26 | — | — | WO | claimed |
| EP-3181550-B1 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | BAYER IP GMBH (DE) | 2019-11-20 | — | — | EP | disclosed |
| US-10093611-B2 | Benzocycloalkenes as antifungal agents | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2018-10-09 | — | — | US | disclosed |
| EP-3181550-A1 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | Bayer Intellectual Property GmbH (DE) | 2017-06-21 | — | — | EP | disclosed |
| US-20160023987-A1 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-01-28 | — | — | US | disclosed |
| US-9173399-B2 | Benzocycloalkenes as antifungal agents | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-11-03 | — | — | US | disclosed |
| EP-2595961-A2 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | Bayer Intellectual Property GmbH (DE) | 2013-05-29 | — | — | EP | disclosed |
| US-20130123322-A1 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-05-16 | — | — | US | disclosed |
| WO-2012010579-A2 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | BAYER CROPSCIENCE AG (DE) | 2012-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160023987-A1 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | CYP51A1, ERG28, CBR1 | SIGMAR1 2549/4885HTR1A 4296/4885ACLY 1426/4885 |
| US-10093611-B2 | Benzocycloalkenes as antifungal agents | CYP51A1, ERG28, CBR1 | SIGMAR1 2549/4885HTR1A 4296/4885ACLY 1426/4885 |
| US-20130123322-A1 | BENZOCYCLOALKENES AS ANTIFUNGAL AGENTS | CYP51A1, ERG28, CBR1 | SIGMAR1 2549/4885HTR1A 4296/4885ACLY 1426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.