Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 6/20 | 0.41 |
| ▸ | MAOA | P21397 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | SNCA | P37840 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5501136 | 0.91 | OPRK1 (0.44) | SIGMAR1OPRK1ADRA2BADRA2CADRA1A | |
| SCHEMBL10960394 | 0.81 | ADRA2B (0.63) | SIGMAR1OPRK1ADRA2BADRA2CADRA1A | |
| SCHEMBL10962781 | 0.81 | TRPA1 (0.42) | SIGMAR1SLC6A2SLC6A4SLC6A3TRPA1 | |
| SCHEMBL10960654 | 0.80 | SIGMAR1 (0.53) | SIGMAR1OPRK1ADRA2BADRA2CADRA1A | |
| SCHEMBL10961165 | 0.78 | SIGMAR1 (0.42) | SIGMAR1OPRK1ADRA2BADRA2CADRA1A | |
| SCHEMBL597722 | 0.78 | SLC6A2 (0.48) | SIGMAR1OPRK1ADRA2BADRA2CADRA1A | |
| SCHEMBL27544524 | 0.77 | NR4A2 (0.49) | SIGMAR1OPRK1ADRA2BADRA2CADRA1A | |
| Hydrochloric Acid SCHEMBL10965588 | 0.77 | SIGMAR1 (0.41) | SIGMAR1OPRK1ADRA2BADRA2CADRA1A | |
| SCHEMBL10961664 | 0.76 | NPSR1 (0.46) | SIGMAR1OPRK1ADRA2BADRA2CADRA1A | |
| SCHEMBL5463181 | 0.71 | CYP1A2 (0.46) | SIGMAR1OPRK1ADRA2BADRA2CADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0053389-B1 | PROCESS FOR PREPARING CATIONIC SURFACE ACTIVE AGENTS | TOHO CHEMICAL INDUSTRY CO., LTD. (JP) | 1985-04-03 | — | — | EP | claimed |
| EP-0053389-A1 | Process for preparing cationic surface active agents | TOHO CHEMICAL INDUSTRY CO., LTD. (JP) | 1982-06-09 | — | — | EP | claimed |
| CN-102153620-A | Process for producing optically active piperazine compound | SUMITOMO CHEMICAL CO | 2011-08-17 | — | — | CN | disclosed |
| CN-102126982-A | Process for producing optically active piperazine compound | SUMITOMO CHEMICAL CO | 2011-07-20 | — | — | CN | disclosed |
| CN-102126978-A | Process for producing optically active piperazine compound | SUMITOMO CHEMICAL CO | 2011-07-20 | — | — | CN | disclosed |
| US-20090275749-A1 | PRODUCTION METHOD OF OPTICALLY ACTIVE PIPERAZINE COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-11-05 | — | — | US | disclosed |
| CN-101312955-A | Process for producing optically active piperazine compound | SUMITOMO CHEMICAL CO (JP) | 2008-11-26 | — | — | CN | disclosed |
| EP-1930325-A1 | PROCESS FOR PRODUCING OPTICALLY ACTIVE PIPERAZINE COMPOUND | Sumitomo Chemical Company, Limited (JP) | 2008-06-11 | — | — | EP | disclosed |
| EP-1136470-B1 | PROCESS FOR THE PREPARATION OF A PIPERAZINE DERIVATIVE | SUMITOMO CHEMICAL CO (JP) | 2007-08-22 | — | — | EP | disclosed |
| US-6495685-B1 | COMPRISING REACTING 1-METHYL-3-PHENYLPIPERAZINE WITH 2-CHLORO-3-CYANOPYRIDINE IN AN APROTIC POLAR ORGANIC SOLVENT IN THE PRESENCE OF A BASE AND AN ALKALI METAL HALIDE. THE PIPERAZINE DERIVATIVE AND ITS OXALATE ARE COMPOUNDS AS | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2002-12-17 | — | — | US | disclosed |
| EP-1136470-A1 | PROCESS FOR THE PREPARATION OF A PIPERAZINE DERIVATIVE | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2001-09-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275749-A1 | PRODUCTION METHOD OF OPTICALLY ACTIVE PIPERAZINE COMPOUND | CYP51A1, CYP4Z1, CYP4A11 | SIGMAR1 1931/4885OPRK1 745/4885ADRA2B 278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.