Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CDC25B | P30305 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8074423 | 0.84 | CDC25B (0.56) | PLK1NR4A1NR4A2NR4A3CDC25B | |
| SCHEMBL28319862 | 0.80 | NPC1 (0.44) | MAPTNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL5046741 | 0.80 | NR4A1 (0.58) | PLK1MMP3HDAC8NR4A1NR4A2 | |
| SCHEMBL14639033 | 0.79 | LMNA (0.50) | MAPTKMT2AKDM4EALDH1A1POLB | |
| SCHEMBL7640335 | 0.78 | PLK1 (0.58) | PLK1MMP3HDAC8NR4A1NR4A2 | |
| SCHEMBL13734754 | 0.78 | POLB (0.46) | MAPTRAB9AKMT2AKDM4EALDH1A1 | |
| SCHEMBL27981110 | 0.78 | CTSD (0.51) | MAPTNPC1RAB9AKMT2APOLB | |
| SCHEMBL29487353 | 0.78 | POLB (0.46) | MAPTRAB9AKMT2AKDM4EALDH1A1 | |
| SCHEMBL27152360 | 0.78 | PKM (0.48) | MAPTNPC1RAB9APTPN1KMT2A | |
| SCHEMBL27874622 | 0.78 | KMT2A (0.42) | MAPTNPC1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113004498-B | Optically active spiral polycarbocarbene block copolymer and preparation method thereof | 合肥工业大学 | 2022-05-31 | — | — | CN | claimed |
| CN-113004498-A | Optically active spiral polycarbocarbene block copolymer and preparation method thereof | 合肥工业大学 | 2021-06-22 | — | — | CN | claimed |
| CN-113004498-B | Optically active spiral polycarbocarbene block copolymer and preparation method thereof | 合肥工业大学 | 2022-05-31 | — | — | CN | disclosed |
| CN-113004498-A | Optically active spiral polycarbocarbene block copolymer and preparation method thereof | 合肥工业大学 | 2021-06-22 | — | — | CN | disclosed |
| CN-101400642-A | Cyclopropane compounds with central nervous system activity | UNIV NEW YORK (US) | 2009-04-01 | — | — | CN | disclosed |
| US-7501453-B2 | Cyclopropanes with central nervous system activity | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2009-03-10 | — | — | US | disclosed |
| US-20070244201-A1 | Cyclopropanes with central nervous system activity | NIH-DEITR | 2007-10-18 | — | — | US | disclosed |
| US-6025502-A | CATALYTICALLY REACTING AN ARYL HYDRAZONE SUBSTITUTED ACETATE ESTER WITH A NITROGEN HETEROCYCLIC COMPOUND WHICH HAS THE NITROGEN PROTECTED, THEN DEPROTECTING | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2000-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244201-A1 | Cyclopropanes with central nervous system activity | PMP22, CNR1, CNR2 | PLK1 3962/4885MMP3 2075/4885HDAC8 1066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.