Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.83 |
| ▸ | LMNA | P02545 | 1/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.83 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL3726684 | 0.93 | MEN1 (0.71) | MEN1LMNAKMT2ATSHR | |
| Tromethamine SCHEMBL17484 | 0.91 | MEN1 (1.00) | MEN1LMNAKMT2AKDM4EPOLB | |
| Tromethamine SCHEMBL975 | 0.91 | — | — | |
| Tromethamine SCHEMBL3696191 | 0.91 | — | — | |
| Tromethamine SCHEMBL6427079 | 0.87 | — | — | |
| Tromethamine SCHEMBL445853 | 0.87 | MEN1 (0.91) | MEN1LMNAKMT2AKDM4EPOLB | |
| Tromethamine SCHEMBL7126002 | 0.87 | — | — | |
| Tromethamine SCHEMBL9298764 | 0.87 | — | — | |
| Tromethamine SCHEMBL2035496 | 0.87 | — | — | |
| Tromethamine SCHEMBL8379571 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070261720-A1 | Voc Free Coatings Strippers | VOCFREE, INC. | 2007-11-15 | — | — | US | disclosed |
| EP-1615987-A4 | VOC FREE COATINGS STRIPPERS | VOCFREE INC (US) | 2006-07-05 | — | — | EP | disclosed |
| EP-1615987-A1 | VOC FREE COATINGS STRIPPERS | Vocfree, Inc. (US) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004090085-A1 | VOC FREE COATINGS STRIPPERS | VOCFREE, INC. (US) | 2004-10-21 | — | — | WO | disclosed |
| US-5294649-A | Hardening agent of magnesioum hydroxide or lightburned magnesium oxide and promoter of a nitrogen-containing heterocyclic compound | BORDEN, INC. (US) | 1994-03-15 | — | — | US | disclosed |
| US-5223554-A | Comprising anions of cyanate, formate, hypophosphite, nitrate, phosphite and sulfamate; used with magnesium hardening agent | BORDEN, INC. (US) | 1993-06-29 | — | — | US | disclosed |
| US-5214079-A | Magnesium oxide or hydroxide | BORDEN, INC. (US) | 1993-05-25 | — | — | US | disclosed |
| US-5182346-A | Magnesium oxide or hydroxide, chelating agent | BORDEN, INC. (US) | 1993-01-26 | — | — | US | disclosed |