Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.56 |
| ▸ | CA6 | P23280 | 5/20 | 0.56 |
| ▸ | CA7 | P43166 | 5/20 | 0.56 |
| ▸ | CA9 | Q16790 | 5/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.56 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | RECQL | P46063 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 4/20 | 0.53 |
| ▸ | CA4 | P22748 | 4/20 | 0.53 |
| ▸ | CA5A | P35218 | 4/20 | 0.53 |
| ▸ | CA3 | P07451 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL19520453 | 0.93 | CA12 (0.48) | CA12CA6CA7CA9CA14 | |
| Tromethamine SCHEMBL17451289 | 0.85 | MEN1 (0.46) | CA12CA6CA7CA9CA14 | |
| SCHEMBL15202478 | 0.85 | CA12 (0.46) | CA12CA6CA7CA9CA14 | |
| Tromethamine SCHEMBL15352164 | 0.80 | LMNA (0.40) | CA12CA6CA7CA9CA14 | |
| Tromethamine SCHEMBL9751476 | 0.80 | MEN1 (0.59) | LMNAMEN1KMT2A | |
| Tromethamine SCHEMBL434887 | 0.80 | MEN1 (0.59) | LMNAMEN1KMT2A | |
| Tromethamine SCHEMBL9751475 | 0.80 | MEN1 (0.59) | LMNAMEN1KMT2A | |
| Tromethamine SCHEMBL16097102 | 0.79 | MEN1 (0.50) | CA12CA6CA7CA9CA14 | |
| Tromethamine SCHEMBL3761763 | 0.78 | MEN1 (0.77) | LMNAMEN1KMT2AALDH1A1KDM4E | |
| Tromethamine SCHEMBL11438714 | 0.76 | MEN1 (0.71) | LMNAMEN1KMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115364692-B | Air filtration composite membrane prepared based on cellulose nanofiber reinforced hydrogel conversion and preparation method thereof | 中国科学院上海高等研究院 | 2023-08-25 | — | — | CN | claimed |
| CN-113152090-B | Antibacterial and antiviral cellulose nanofiber filtering protective film and preparation method thereof | 东华大学 | 2023-04-28 | — | — | CN | claimed |
| CN-115364692-A | Air filtration composite membrane prepared based on cellulose nanofiber reinforced hydrogel conversion and preparation method thereof | 中国科学院上海高等研究院 | 2022-11-22 | — | — | CN | claimed |
| CN-113152090-A | Antibacterial and antiviral cellulose nanofiber filtering and protecting membrane and preparation method thereof | 东华大学 | 2021-07-23 | — | — | CN | claimed |
| CN-107817650-B | Latent additive and composition containing the same | 株式会社艾迪科 | 2024-07-02 | — | — | CN | disclosed |
| CN-110023307-B | Oxime ester compound and photopolymerization initiator containing the same | 株式会社艾迪科 | 2024-01-02 | — | — | CN | disclosed |
| CN-115364692-B | Air filtration composite membrane prepared based on cellulose nanofiber reinforced hydrogel conversion and preparation method thereof | 中国科学院上海高等研究院 | 2023-08-25 | — | — | CN | disclosed |
| CN-113152090-B | Antibacterial and antiviral cellulose nanofiber filtering protective film and preparation method thereof | 东华大学 | 2023-04-28 | — | — | CN | disclosed |
| CN-113152090-B | Antibacterial and antiviral cellulose nanofiber filtering protective film and preparation method thereof | 东华大学 | 2023-04-28 | — | — | CN | disclosed |
| CN-115364692-A | Air filtration composite membrane prepared based on cellulose nanofiber reinforced hydrogel conversion and preparation method thereof | 中国科学院上海高等研究院 | 2022-11-22 | — | — | CN | disclosed |
| CN-113152090-A | Antibacterial and antiviral cellulose nanofiber filtering and protecting membrane and preparation method thereof | 东华大学 | 2021-07-23 | — | — | CN | disclosed |
| WO-2020250880-A1 | CARBAMOYL OXIME COMPOUND, AND POLYMERIZATION INITIATOR AND POLYMERIZABLE COMPOSITION CONTAINING SAID COMPOUND | 株式会社ADEKA | 2020-12-17 | — | — | WO | disclosed |
| WO-2020250879-A1 | CARBAMOYL OXIME COMPOUND, AND POLYMERIZATION INITIATOR AND POLYMERIZABLE COMPOSITION CONTAINING SAID COMPOUND | 株式会社ADEKA | 2020-12-17 | — | — | WO | disclosed |
| WO-2020241529-A1 | CARBAMOYL OXIME COMPOUND, AND POLYMERIZATION INITIATOR AND POLYMERIZABLE COMPOSITION CONTAINING SAID COMPOUND | 株式会社ADEKA | 2020-12-03 | — | — | WO | disclosed |
| US-20130296455-A1 | NOVEL COMPOUND, DYE AND COLORED PHOTOSENSITIVE COMPOSITION | ADEKA CORPORATION (JP) | 2013-11-07 | — | — | US | disclosed |
| WO-2004079407-A1 | HIGH REFRACTIVE INDEX LAYER PRODUCTION PROCESS OF CURABLE COATING COMPOSITION, ANTIREFLECTION FILM, POLARIZING PLATE AND IMAGE DISPLAY DEVICE USING THEREOF | FUJI PHOTO FILM CO., LTD. (JP) | 2004-09-16 | — | — | WO | disclosed |
| EP-1115751-A4 | PHOTOPOLYMERIZATION PROCESS AND COMPOSITION EMPLOYING A CHARGE TRANSFER COMPLEX AND CATIONIC PHOTOINITIATOR | FUSION UV SYS INC (US) | 2002-08-14 | — | — | EP | disclosed |
| EP-1115751-A1 | PHOTOPOLYMERIZATION PROCESS AND COMPOSITION EMPLOYING A CHARGE TRANSFER COMPLEX AND CATIONIC PHOTOINITIATOR | Fusion Uv Systems, Inc. (US) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000006613-A1 | PHOTOPOLYMERIZATION PROCESS AND COMPOSITION EMPLOYING A CHARGE TRANSFER COMPLEX AND CATIONIC PHOTOINITIATOR | FUSION UV SYSTEMS, INC. (US) | 2000-02-10 | — | — | WO | disclosed |