SCHEMBL4349570

SCHEMBL4349570

CC(O)COC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ DPP8 Q6V1X1 2/20 0.46
▸ DPP9 Q86TI2 2/20 0.46
▸ DPP7 Q9UHL4 2/20 0.46
▸ GNAI3 P08754 1/20 0.43
▸ GNAO1 P09471 1/20 0.43
▸ GNAI1 P63096 1/20 0.43
▸ ERAP2 Q6P179 6/20 0.42
▸ LNPEP Q9UIQ6 4/20 0.42
▸ ERAP1 Q9NZ08 3/20 0.41
▸ DPP4 P27487 1/20 0.41
▸ GSR P00390 1/20 0.40
▸ TLR2 O60603 2/20 0.39
▸ NMT2 O60551 1/20 0.37
▸ NMT1 P30419 1/20 0.37
▸ SSTR5 P35346 2/20 0.37
▸ GLA P06280 1/20 0.37
▸ TDP1 Q9NUW8 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13496274 0.84 ERAP2 (0.54) DPP8DPP9DPP7GNAI3GNAO1
SCHEMBL29194171 0.82 GSR (0.50) DPP8DPP9DPP7GNAI3GNAO1
SCHEMBL2734207 0.81 ERAP2 (0.52) DPP8DPP9DPP7GNAI3GNAO1
SCHEMBL3485077 0.78 DPP7 (0.58) DPP8DPP9DPP7GNAI3GNAO1
SCHEMBL6844633 0.78 DPP8 (0.46) DPP8DPP9DPP7GNAI3GNAO1
SCHEMBL22769258 0.78 DPP8 (0.43) DPP8DPP9DPP7GNAI3GNAO1
SCHEMBL14453693 0.77 DPP7 (0.54) DPP8DPP9DPP7GNAI3GNAO1
SCHEMBL7747523 0.77 DPP7 (0.58) DPP8DPP9DPP7GNAI3GNAO1
SCHEMBL503847 0.77 DPP7 (0.58) DPP8DPP9DPP7GNAI3GNAO1
SCHEMBL21027659 0.77 DPP8 (0.50) DPP8DPP9DPP7GNAI3GNAO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8846893-B2 Non-ionically bound constructs, and compositions and kits comprising domains ENZO BIOCHEM, INC. (US) 2014-09-30 — — US disclosed
US-8742090-B2 Property effecting and/or property exhibiting compositions for therapeutic and diagnostic uses ENZO BIOCHEM, INC. (US) 2014-06-03 — — US disclosed
US-8735145-B2 Property effecting and/or property exhibiting compositions for therapeutic and diagnostic uses ENZO BIOCHEM, INC. (US) 2014-05-27 — — US disclosed
EP-2042606-A1 Novel property effecting and/or property exhibiting compositions for therapeutic and diagnostic use ENZO THERAPEUTICS, INC. (US) 2009-04-01 — — EP disclosed
US-20080248564-A1 Expression vector comprising ligand conjugates for use and expression of heterologus nucleotide sequences in cells ENZO THERAPEUTICS, INC. (US) 2008-10-09 — — US disclosed
EP-0779365-B1 Methods to introduce nucleic acid into cells for therapeutic and diagnostic uses ENZO THERAPEUTICS INC (US) 2008-09-17 — — EP disclosed
US-20080108139-A1 Expression vector comprising nucleotide sequences coding polymerase for use in eukaryotic specific expression of functional heterologous proteins ENZO THERAPEUTICS, INC. (US) 2008-05-08 — — US disclosed
US-20030104620-A1 Expression vector for expression of heterologous polypeptides and amplification of cell viral resistance; viricides ENZO BIOCHEM, INC. 2003-06-05 — — US disclosed
US-20030087434-A1 Expression vector for use gene transfer tool in genetic engineering ENZO BIOCHEM, INC. 2003-05-08 — — US disclosed
US-20010007767-A1 Genetic engineering ENZO BIOCHEM, INC. 2001-07-12 — — US disclosed
US-20010006816-A1 Dna, rna hybrid ENZO BIOCHEM, INC. 2001-07-05 — — US disclosed
US-20010006815-A1 Chemical modification ENZO BIOCHEM, INC. 2001-07-05 — — US disclosed
US-20010006814-A1 Chemical modification ENZO BIOCHEM, INC. 2001-07-05 — — US disclosed
EP-0779365-A2 Methods to introduce nucleic acid into cells for therapeutic and diagnostic uses ENZO THERAPEUTICS, INC. (US) 1997-06-18 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030104620-A1 Expression vector for expression of heterologous polypeptides and amplification of cell viral resistance; viricides HAVCR2, RNASE1, RNPEP DPP8 747/4885DPP9 605/4885DPP7 563/4885
US-20010006814-A1 Chemical modification RNASE1, DNASE1L3, DNASE1 DPP8 1009/4885DPP9 838/4885DPP7 1131/4885
US-20080108139-A1 Expression vector comprising nucleotide sequences coding polymerase for use in eukaryotic specific expression of functional heterologous proteins RNGTT, RNASE1, MRPL21 DPP8 2487/4885DPP9 2695/4885DPP7 2107/4885
US-20030087434-A1 Expression vector for use gene transfer tool in genetic engineering RNASE1, GUSB, DCLRE1B DPP8 2540/4885DPP9 1965/4885DPP7 2015/4885
US-20010007767-A1 Genetic engineering DCLRE1B, RNASE1, DNASE1L3 DPP8 2048/4885DPP9 1789/4885DPP7 2070/4885
US-20010006815-A1 Chemical modification RNASE1, DNASE1L3, DNASE1 DPP8 1009/4885DPP9 838/4885DPP7 1131/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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