Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.47 |
| ▸ | TPMT | P51580 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775500 | 0.79 | HSD17B10 (0.56) | HSD17B10ALDH1A1KDM4ETPMTMAPT | |
| SCHEMBL3558535 | 0.79 | KDM4E (0.42) | HSD17B10ALDH1A1KDM4EPDE4DMAPT | |
| SCHEMBL19063459 | 0.76 | PDE4D (0.42) | HSD17B10ALDH1A1KDM4EPDE4DTPMT | |
| SCHEMBL28440693 | 0.75 | AKR1C2 (0.52) | HSD17B10ALDH1A1KDM4EMAPTTDP1 | |
| SCHEMBL392397 | 0.75 | TSHR (0.48) | ALDH1A1KDM4EMAPTTDP1MEN1 | |
| SCHEMBL5765625 | 0.75 | PPARG (0.45) | — | |
| SCHEMBL30084374 | 0.73 | ACLY (0.56) | HSD17B10ALDH1A1KDM4ETPMTMAPT | |
| SCHEMBL423692 | 0.73 | ACLY (0.56) | HSD17B10ALDH1A1KDM4ETPMTMAPT | |
| SCHEMBL477714 | 0.73 | TSHR (0.57) | HSD17B10ALDH1A1KDM4EMAPTTDP1 | |
| SCHEMBL29157397 | 0.72 | HCAR2 (0.39) | ALDH1A1KDM4EMAPTTDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069305-A2 | NICOTINIC ACID DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Novartis AG (CH) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008031550-A2 | NICOTINIC ACID DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTANATE RECEPTORS | NOVARTIS AG (CH) | 2008-03-20 | — | — | WO | disclosed |