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SCHEMBL4352666

SCHEMBL4352666

CC(C)(C)OC(=O)N1CCC(C2OCc3cc(-c4ccc(C(=O)N5CCN(c6ncccn6)CC5)cn4)ccc3O2)CC1

nearest known ligand 0.49

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 8/20 0.49
▸ LMNA P02545 2/20 0.46
▸ TDP1 Q9NUW8 1/20 0.44
▸ SLC6A7 Q99884 4/20 0.41
▸ DYRK2 Q92630 1/20 0.40
▸ ALDH1A1 P00352 1/20 0.39
▸ TSHR P16473 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ HSD17B10 Q99714 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4354311 0.91 GPR119 (0.44) GPR119LMNADYRK2
SCHEMBL4347903 0.89 GPR119 (0.44) GPR119LMNA
SCHEMBL4350001 0.89 SLC6A7 (0.46) SLC6A7ALDH1A1TSHR
SCHEMBL4355713 0.88 SLC6A7 (0.44) GPR119LMNASLC6A7ALDH1A1TSHR
SCHEMBL4351360 0.87 GPR119 (0.42) GPR119DYRK2
SCHEMBL4536512 0.86 GPR119 (0.47) GPR119
SCHEMBL13586034 0.81 ABL1 (0.46) GPR119
SCHEMBL4355704 0.81 RAB9A (0.46) ALDH1A1
SCHEMBL4352054 0.81 GPR119 (0.46) GPR119
SCHEMBL13586046 0.80 GPR119 (0.57) GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009150144-A1 NEW GPR119MODULATORS INOVACIA AB (SE) 2009-12-17 — — WO claimed
WO-2009150144-A1 NEW GPR119MODULATORS INOVACIA AB (SE) 2009-12-17 — — WO disclosed