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SCHEMBL4354311

SCHEMBL4354311

CN1CCN(C(=O)c2ccc(-c3ccc4c(c3)COC(C3CCN(C(=O)OC(C)(C)C)CC3)O4)nc2)CC1

nearest known ligand 0.44

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 11/20 0.44
▸ TP53 P04637 3/20 0.42
▸ THRB P10828 1/20 0.42
▸ STAT3 P40763 1/20 0.41
▸ RXFP1 Q9HBX9 1/20 0.41
▸ DYRK2 Q92630 1/20 0.41
▸ ROCK2 O75116 1/20 0.40
▸ HDAC4 P56524 1/20 0.40
▸ CRBN Q96SW2 1/20 0.40
▸ LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4347903 0.93 GPR119 (0.44) GPR119LMNA
SCHEMBL4351360 0.93 GPR119 (0.42) GPR119STAT3DYRK2HDAC4CRBN
SCHEMBL4352666 0.91 GPR119 (0.49) GPR119DYRK2LMNA
SCHEMBL4536512 0.90 GPR119 (0.47) GPR119
SCHEMBL13586034 0.90 ABL1 (0.46) GPR119TP53THRBRXFP1ROCK2
SCHEMBL4355704 0.90 RAB9A (0.46) STAT3ROCK2
SCHEMBL4536116 0.88 STAT3 (0.43) STAT3ROCK2
SCHEMBL4355344 0.86 GPR119 (0.43) GPR119TP53THRBRXFP1DYRK2
SCHEMBL4532442 0.86 STAT3 (0.43) STAT3ROCK2
SCHEMBL4352054 0.85 GPR119 (0.46) GPR119ROCK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009150144-A1 NEW GPR119MODULATORS INOVACIA AB (SE) 2009-12-17 — — WO claimed
WO-2009150144-A1 NEW GPR119MODULATORS INOVACIA AB (SE) 2009-12-17 — — WO disclosed
WO-2009150144-A1 NEW GPR119MODULATORS INOVACIA AB (SE) 2009-12-17 — — WO disclosed