SCHEMBL4354693

SCHEMBL4354693

ClCC[SiH](Oc1ccccc1)Oc1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 3/20 0.36
TSHR P16473 2/20 0.36
KCNA3 P22001 1/20 0.36
CA4 P22748 1/20 0.33
ALDH1A1 P00352 2/20 0.32
TAAR1 Q96RJ0 1/20 0.32
RECQL P46063 1/20 0.32
SRC P12931 1/20 0.32
PKM P14618 1/20 0.31
L3MBTL1 Q9Y468 2/20 0.31
TDP1 Q9NUW8 1/20 0.31
ALOX15 P16050 1/20 0.31
RNF4 P78317 1/20 0.31
SMN1; SMN2 Q16637 2/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
SLC22A2 O15244 1/20 0.30
SLC22A1 O15245 1/20 0.30
SLC22A3 O75751 1/20 0.30
ESR1 P03372 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4361022 0.85 KCNA3 (0.41) LTA4HTSHRKCNA3ALDH1A1TAAR1
SCHEMBL2231315 0.81 LTA4H (0.39) LTA4HTSHRKCNA3CA4ALDH1A1
SCHEMBL2229313 0.77 LTA4H (0.36) LTA4HTSHRKCNA3CA4ALDH1A1
SCHEMBL712986 0.77 LTA4H (0.41) LTA4HTSHRKCNA3CA4L3MBTL1
SCHEMBL11276834 0.76 L3MBTL1 (0.30) LTA4HTSHRALDH1A1L3MBTL1SMN1; SMN2
SCHEMBL704612 0.76 ALDH1A1 (0.41) ALDH1A1TAAR1TDP1ALOX15SMN1; SMN2
SCHEMBL706800 0.74 LTA4H (0.47) LTA4HKCNA3CA4ALDH1A1SMN1; SMN2
SCHEMBL1781213 0.72 ALDH1A1 (0.39) LTA4HTSHRKCNA3ALDH1A1TAAR1
SCHEMBL4363258 0.72 KCNA3 (0.37) LTA4HTSHRKCNA3CA4ALDH1A1
SCHEMBL3350917 0.72 HDAC3 (0.52) LTA4HTSHRKCNA3CA4DRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7619108-B2 Process for preparing unsaturated organosilicon compounds WACKER CHEMIE AG (DE) 2009-11-17 US disclosed
US-20080293958-A1 Process for Preparing Unsaturated Organosilicon Compounds WACKER CHEMIE AG (DE) 2008-11-27 US disclosed
US-6815554-B2 REACTING A HALOALKYLSILANE WITH A SALT OF AN UNSATURATED CARBOXYLIC ACID IN THE PRESENCE OF A PHASE TRANSFER CATALYST; BONDING AGENTS WACKER-CHEMIE GMBH (DE) 2004-11-09 US disclosed
US-20020151736-A1 PROCESS FOR PREPARING UNSATURATED ORGANOSILICON COMPOUNDS WACKER-CHEMIE GMBH (DE) 2002-10-17 US disclosed