SCHEMBL2229313

SCHEMBL2229313

BrCC[SiH](Oc1ccccc1)Oc1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 3/20 0.36
TSHR P16473 2/20 0.36
TDP1 Q9NUW8 1/20 0.36
KCNA3 P22001 1/20 0.36
ALDH1A1 P00352 2/20 0.33
TRPA1 O75762 1/20 0.33
CA4 P22748 1/20 0.33
SCN4A P35499 2/20 0.32
TAAR1 Q96RJ0 1/20 0.32
RECQL P46063 1/20 0.32
PKM P14618 1/20 0.31
ALOX15 P16050 1/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
CA5A P35218 1/20 0.30
CA5B Q9Y2D0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4363258 0.85 KCNA3 (0.37) LTA4HTSHRTDP1KCNA3ALDH1A1
SCHEMBL712986 0.77 LTA4H (0.41) LTA4HTSHRKCNA3CA4
SCHEMBL4354693 0.77 LTA4H (0.36) LTA4HTSHRTDP1KCNA3ALDH1A1
SCHEMBL1781213 0.77 ALDH1A1 (0.39) LTA4HTSHRKCNA3ALDH1A1TAAR1
SCHEMBL704612 0.76 ALDH1A1 (0.41) TDP1ALDH1A1TAAR1ALOX15NPC1
SCHEMBL706800 0.74 LTA4H (0.47) LTA4HKCNA3ALDH1A1CA4SMN1; SMN2
SCHEMBL3350917 0.72 HDAC3 (0.52) LTA4HTSHRKCNA3CA4
SCHEMBL704670 0.72 DRD2 (0.44) LTA4HTDP1NPC1RAB9ASMN1; SMN2
SCHEMBL19927175 0.72 LTA4H (0.47) LTA4HTSHRKCNA3ALDH1A1SMN1; SMN2
SCHEMBL4361022 0.72 KCNA3 (0.41) LTA4HTSHRKCNA3ALDH1A1TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0447066-B2 Pneumatic tyres BRIDGESTONE CORP (JP) 2000-08-16 EP claimed
US-5409969-A Comprising silica filler, carbon black, silane coupler, living polymer of butadiene-styrene BRIDGESTONE CORPORATION (JP) 1995-04-25 US claimed
EP-0447066-A1 Pneumatic tyres Bridgestone Corporation (JP) 1991-09-18 EP claimed
US-5017636-A Also containing polyisoprene, natural rubber, butadiene-styrene copolymer, wear and heat resistance, resilience JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1991-05-21 US claimed
EP-1721930-B1 RUBBER COMPOSITION JSR CORP (JP) 2015-01-28 EP disclosed
US-7981966-B2 Rubber composition JSR CORPORATION (JP) 2011-07-19 US disclosed
US-7619108-B2 Process for preparing unsaturated organosilicon compounds WACKER CHEMIE AG (DE) 2009-11-17 US disclosed
US-20080293958-A1 Process for Preparing Unsaturated Organosilicon Compounds WACKER CHEMIE AG (DE) 2008-11-27 US disclosed
US-20070208126-A1 Vulcanizable rubber composition, in particular for low rolling resistance treads of vehicle tires PIRELLI PNEUMATICI S.P.A. 2007-09-06 US disclosed
US-20070185267-A1 Rubber composition JSR CORPORATION (JP) 2007-08-09 US disclosed
EP-1721930-A1 RUBBER COMPOSITION JSR Corporation (JP) 2006-11-15 EP disclosed
EP-0992537-B1 Oil extended rubber and rubber composition JSR CORP (JP) 2004-12-29 EP disclosed
EP-0934973-A1 Vulcanizable rubber composition, in particular for low rolling resistance treads of vehicle tires PIRELLI PNEUMATICI S.p.A. (IT) 1999-08-11 EP disclosed
US-5496883-A COMPRISING TREAD RUBBER OF POLYBUTADIENE POLYMER OR COPOLYMER CONTAINING SILICA AND MODIFIED WITH SILANE COUPLING AGENT; COUPLING AGENT; WET SKID RESISTANCE, LOW ROLLLING RESISTANCE BRIDGESTONE CORPORATION (JP) 1996-03-05 US disclosed
US-5409969-A Comprising silica filler, carbon black, silane coupler, living polymer of butadiene-styrene BRIDGESTONE CORPORATION (JP) 1995-04-25 US disclosed
EP-0299074-B1 TIRE Bridgestone Corporation (JP) 1992-01-29 EP disclosed
US-5066721-A TIRES MADE OF SILICA FILLED, SILANE MODIFIED RUBBER BRIDGESTONE CORPORATION (JP) 1991-11-19 US disclosed
EP-0447066-A1 Pneumatic tyres Bridgestone Corporation (JP) 1991-09-18 EP disclosed
US-5017636-A Also containing polyisoprene, natural rubber, butadiene-styrene copolymer, wear and heat resistance, resilience JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1991-05-21 US disclosed
EP-0299074-A1 TIRE Bridgestone Corporation (JP) 1989-01-18 EP disclosed