Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 12/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 11/20 | 0.44 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.35 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4355044 | 0.83 | MTNR1A (0.40) | MTNR1BMTNR1AGCGRMAPTNPSR1 | |
| SCHEMBL4355054 | 0.80 | GCGR (0.47) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL4355057 | 0.80 | GCGR (0.40) | MTNR1BMTNR1AGCGRMAPTNPSR1 | |
| SCHEMBL4046896 | 0.79 | GCGR (0.37) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL4042850 | 0.77 | GCGR (0.64) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL8886980 | 0.63 | MTNR1A (0.59) | MTNR1BMTNR1ANQO2 | |
| SCHEMBL12964162 | 0.62 | MTNR1A (0.64) | MTNR1BMTNR1ANQO2 | |
| SCHEMBL15286705 | 0.61 | HTR6 (0.49) | MTNR1BMTNR1A | |
| SCHEMBL4045250 | 0.61 | GCGR (0.71) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL1567238 | 0.61 | MTNR1A (0.55) | MTNR1BMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549655-B1 | SUBSTITUTED BICYCLIC THIOPHENE DERIVATIVES, COMPOSTIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 2009-01-21 | — | — | EP | claimed |