Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.40 |
| ▸ | GCGR | P47871 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.37 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4355052 | 0.83 | MTNR1B (0.44) | MTNR1AMTNR1BGCGRMAPTNPSR1 | |
| SCHEMBL4355054 | 0.80 | GCGR (0.47) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL4355057 | 0.80 | GCGR (0.40) | MTNR1AMTNR1BGCGRMAPTNPSR1 | |
| SCHEMBL4042850 | 0.78 | GCGR (0.64) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL4046896 | 0.71 | GCGR (0.37) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL4045250 | 0.62 | GCGR (0.71) | GCGRMAPTNPSR1SAE1UBA2 | |
| SCHEMBL15286705 | 0.61 | HTR6 (0.49) | MTNR1AMTNR1B | |
| SCHEMBL12964162 | 0.60 | MTNR1A (0.64) | MTNR1AMTNR1B | |
| SCHEMBL9731275 | 0.60 | MTNR1A (1.00) | MTNR1AMTNR1BMAPTALOX15 | |
| SCHEMBL24105927 | 0.59 | MTNR1A (0.53) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549655-B1 | SUBSTITUTED BICYCLIC THIOPHENE DERIVATIVES, COMPOSTIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 2009-01-21 | — | — | EP | claimed |