Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 2/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.34 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4355052 | 0.80 | MTNR1B (0.44) | GCGRMTNR1AMTNR1BMAPTNPSR1 | |
| SCHEMBL4355044 | 0.80 | MTNR1A (0.40) | GCGRMTNR1AMTNR1BALDH1A1NPC1 | |
| SCHEMBL4355054 | 0.79 | GCGR (0.47) | GCGRALDH1A1NPC1RAB9AALOX15 | |
| SCHEMBL4042850 | 0.77 | GCGR (0.64) | GCGRALDH1A1NPC1RAB9AALOX15 | |
| SCHEMBL4046896 | 0.70 | GCGR (0.37) | GCGRALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL15286705 | 0.62 | HTR6 (0.49) | MTNR1AMTNR1B | |
| SCHEMBL4045250 | 0.61 | GCGR (0.71) | GCGRALDH1A1NPC1RAB9AALOX15 | |
| SCHEMBL1567238 | 0.59 | MTNR1A (0.55) | MTNR1AMTNR1B | |
| SCHEMBL31074970 | 0.59 | MAPK10 (0.58) | ALDH1A1NPC1RAB9AMAPK1MAPT | |
| SCHEMBL9731275 | 0.58 | MTNR1A (1.00) | MTNR1AMTNR1BALOX15MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549655-B1 | SUBSTITUTED BICYCLIC THIOPHENE DERIVATIVES, COMPOSTIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 2009-01-21 | — | — | EP | claimed |